右美沙芬治疗特发性眼睑痉挛的回顾性分析.pdfVIP

International Journal of Psychiatry and Neurology 国际神经精神科学杂志, 2017, 6(3), 44-49 Published Online August 2017 in Hans. /journal/ijpn /10.12677/ijpn.2017.63008 A Retrospective Study on the Therapeutic Effect of Dextromethorphan on Essential Blepharospasm Xuesheng Zheng Department of Neurosurgery, Xin Hua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai rd th rd Received: Aug. 3 , 2017; accepted: Aug. 17 , 2017; published: Aug. 23 , 2017 Abstract Background: Blepharospasm is a focal dystonia characterized by intermittent or continual invo- luntary contractions of the facial muscles around both eyes. It causes frequent eyelid closure and visual disturbance. The current therapies for blepharospasm are not satisfactory. Here is a re- trospective study to analyze the therapeutic effect of dextromethorphan on blepharospasm. Me- thods: This retrospective study included 22 patients with blepharospasm. They were treated with dextromethorphan, 30 mg orally three times a day for 4 weeks. The effect of dextromethorphan on essential blepharospasm was evaluated using Jankovic Rating Scale (JRS) and Blepharospasm Disability Index (BSDI). Results: Before treatment, the baseline JRS score was 5.55 ± 1.10 points, and the BSDI score was 2.87 ± 0.59 points. After 1 week of dextromethorphan treatment, the JRS score decreased to 2.82 ± 0.85 points and the BSDI score to 1.36 ± 0.58 points. In the following 3 weeks of dextromethorphan treatment, the JRS and BSDI scores kept in a steady state. One week after the dextromethorphan treatment, the JRS (5.41 ± 1.01 points) and BSDI (2.63 ± 0.64 points) scores returned to the pre-treatment baseline level. Conclusion: W