中科院微生物所高级科研岗位竞聘申请答辩.pdfVIP

Mobile Antibiotic Resistome In Human And Animal Gut Microbiota Baoli Zhu, PhD. Institute of Microbiology, Chinese Academy of Sciences zhubaoli@im.ac.cn Euro-China·2016年10月28 日 中国科学院微生物研究所 Institute of Microbiology, Chinese Academy of Sciences Dissemination of Antibiotic Resistance Genes Julie A. Perry 2014. Bioessays. The circles represent potential anthropogenic antimicrobial selection pressure. Some pathways are well described, while others are plausible but lack substantive evidence. Not all plausible pathways are depicted. 1/27 中国科学院微生物研究所 Institute of Microbiology, Chinese Academy of Sciences Large scale metagenomic analysis Datasets Used in Initial Analysis on Human Gut Microbiota • The 4.1 million human gut gene catalog created BGI (from 85 Danish, 39 Spanish and 38 Chinese gut microbiota). • the Antibiotic Resistance Genes Database (ARDB) : a core set of 7,825 antibiotic resistance genes, which belong to 380 gene types that correspond to 249 antibiotics. 中国科学院微生物研究所 Institute of Microbiology, Chinese Academy of Sciences Different countries have different AR gene types • 1,093 ARGs in the human gut，belonging to 149 AR gene types More than 50% individuals: China 70 types; Denmark 45 types: Spain 49 types. 中国科学院微生物研究所 Institute of Microbiology, Chinese Academy of Sciences Abundance of the resistance genes in China is the highest • To compare the abundances of antibiotic resistance