克唑替尼_____肿瘤治疗新药幻灯片.ppt

* PMID:* * * * * * * * * * * * * * * * From Training review doc * * * From Global Lung Council * From Global Lung Council * From Global Lung Council * * * * * * * * * Based on ALK Resistance Workshop slides (slide 5) * Sasaki manuscript at: /content/early/2011/07/25/0008-5472.CAN-11-1340 * * * * * EML4-ALK的FISH检测中需注意的问题 至少计数50个肿瘤细胞以确保结果的精确性 1 如果红色和绿色探针分离 2个信号直径 ，则认为FISH信号为阳性1 ALK 重排可能遍及整个肿瘤而非局部2 约5%-11%的细胞会出现假阳性分离1,2 ALK重排细胞比例的增加与克唑替尼治疗的肿瘤缓解程度并无关联3 Varella Garcia et al., IASLC 2011; Abs #MTE36.1 2. Camidge et al., Cli