一种肿瘤基因表达数据的知识提取方法.pdfVIP

9 Vol . 32 No. 9 2004 9 ACTA ELECTRONICA SINICA Sep. 2004 1 2 1 李颖新 , 刘全金 , 阮晓钢 ( 11 , 100022; 21 , 246011) : , , . , , , , , . . : DNA ; ; ; ; : TP 18 : A : 037222112 ( 2004) 092 14792 04 A Method for Extracting Knowledge from Tumor Gene Expres sion Data 1 2 1 LI Ying2xin , LIU Qu an2 in , RUAN Xiao2gang ( 11School of ElectronicInformation and Control Engineering,Beijing University of Technology,Beijing 100022, China; 21Department of Physics, nqingNormal College, nqing, nhui 2460 11, China) Ab stract: Based on the gen e expression profiles of mu ltiple myeloma, a method was proposed for knowledge discovery using dat a min ing an d machin e learning methods. We used the information gain as the criterion of each gene for classification, and got a set of informative gen es using artificial neural networks. Identified by decision tree algorithm, production rules were discovered as refer2 ences for b iomedical research ers. The effectiven ess of the method we proposed is proved by experimental results. The method can also b e used as a tool for gene expression analysis in the research of b iomedicine and b iot echnology. Ke y word s : DNA ch ip; gene expression; data min ing; neural networks; multiple myeloma , , 1 DNA ( DNA ) . , , . DNA