年龄相关性黄斑变性的动物模型-解放军医学院学报.pdfVIP

294 解放军医学院学报 Acad J Chin PLA Med Sch Mar 2015，36（3） 年龄相关性黄斑变性的动物模型 1,2 3 1,2 聂　闯 ，罗　灵 ，张卯年 1 2 3 解放军总医院 眼科，北京　100853 ； 解放军医学院，北京　100853 ； 解放军第 306 医院 眼科，北京 　100101 摘要：年龄相关性黄斑变性 (age-related macular degeneration，AMD) 已成为 65 岁以上人群视力损失的主要原因，是一种年龄、 基因、环境等多因素共同作用的慢性疾病，首先表现为 Bruch 膜的损害，随后影响到视网膜色素上皮和光感受器。随着疾 病研究的深入，已发现了越来越多的特殊类型，但是其具体发病机制仍不明确。因此研究者们为了更深入地研究疾病以及 研发新的治疗手段建立了各种各样的动物模型。我们复习了国内外经典以及较新的动物模型文献，并按不同疾病类型进行 综述，希望为研究者寻找理想的动物实验平台提供思路。 关键词 ：年龄相关性黄斑变性 ；动物模型 ；病因学 中图分类号：R774.5 ；R-331　文献标志码：A　文章编号：2095-5227(2015)03-0294-05　DOI ：10.3969/j.issn.2095-5227.2015.03.026 网络出版时间：2014-11-27 10:43　　　 网络出版地址 ：/kcms/detail/11.3275.R1041.002.html Animal models in research on age-related macular degeneration 1,2 3 1,2 NIE Chuang , LUO Ling , ZHANG Maonian 1Department of Ophthalmology, Chinese PLA General Hospital, Beij ing 100853, China; 2Chinese PLA Medical School, Beij ing 100853, China; 3Department of Ophthalmology, The 306th Hospital of PLA, Beij ing 100 10 1, China Corresponding author: ZHANG Maonian. Email: zmn30 1@; LUO Ling. Email: ling.luoling1208@ Abstract: Age-related macular degeneration (AMD) is the leading cause of blindness in the individuals older than 65 years. It is a complex chronic disease influenced by age, genetic and environmental factors. AMD begins in Bruchs membrane and progresses into the retinal pigment epithelium and ultimately the overlying photoreceptors. It has several subtypes. Its etiology still remains unclear and its therapy is still a big challenge. Recently, there are several AMD animal models have been established for research. This article reviews these diversity of animal models, both on their advantages and limitations, in order to provide some details for further study. Keywords: age-related macular degeneration; animal models; etiology 年