蒿属植物在胃肠道疾病防治中的药理作用及其机制研究进展.pdf

• 304 • 现代药物与临床 Drugs Clinic 第 27 卷 第 3 期 2012 年 5 月 蒿属植物在胃肠道疾病防治中的药理作用及其机制研究进展 1 2 1 1 胡厚才 ，谢建光 ，丘丽凰 ，易永基 1. 桂林莱茵生物科技股份有限公司，广西 桂林 541199 2. 华南农业大学 生命科学学院，广东 广州 510642 摘 要：蒿属植物在世界各国胃肠道疾病传统防治中有广泛应用，现代药理研究验证了蒿属植物提取物及其活性成分异泽兰 黄素、dehydryleucodine 等的临床前及临床治疗效果。艾蒿、茵陈等蒿属植物是传统中药，具有广泛的药理活性；然而，国 内对其在胃肠道疾病防治中的应用及现代研究相对滞后。主要综述了蒿属植物在胃肠道疾病防治中的药理作用及其机制研究 进展，以期为蒿属植物的创新应用及中药现代化研究提供借鉴。 关键词：蒿属植物；胃肠道疾病；药理作用；机制 中图分类号：R282.71 ；R285.6 文献标志码：A 文章编号：1674 - 5515(2012)03 - 0304 - 05 Research advances in pharmacologic effect for gastrointestinal protectionof plants in Artemisia L. and their mechanism 1 2 1 1 HU Hou-cai , XIE Jian-guang , QIU Li-huang , YI Yong-ji 1. Layn Natural Ingredient Corp., Guilin 541199, China 2. College of Life Sciences, South China Agricultural University, Guangzhou 510642, China Abstract: Artemisia L. species were used in gastrointestinal protection widely around the world. Modern researches showed that Artemisia L. plant extracts and their active constituents, eupatilin and dehydryleucodine, showed positive effects against gastrointestinal diseases in preclinical and clinical trials. Plants in Artemisia L., such as A. verlotorum and A. scoparia , are widely used in traditional Chinese medicines (TCM) with a wide range of pharmacological activities. However, their application in prevention and treatment of gastrointestinal diseases and their modern researches have lagged behind in our country. This article reviews the pharmacologic effect and the mechanism of the plants in Artemisia L. for gastrointestinal protection, which could provide the reference for innovative application and modernization of TCM. Key words: plants in Artemisia L.; gastrointestinal diseases; pharmacologic effect; mechanism 蒿属（Arternisi