浆细胞病出血和血栓并发症的研究进展.PDF

! 1046! 2010 11 15 11 Ch inese C lin ica l O ncology, N ov. 20 10, V o l. 15, N o. 11 210002 南京 南京军区南京总医院卫生干部训练中心 第二军医大学 2005 级临床医学专业 1, 2 2 徐 超, 于亚平 综述, 翟勇平 审校 , , , , ; ; ; ; : R 730263 : A : 1009- 04 60 ( 2010 11- 1046- 05 B leed ing and throm bosis com p lication s in p lasm a cell dy scrasias X U Chao, YU Yap ing, ZHA I Yong p ing. Second M ilitary M ed ical Univ ers ity, N anj ing G eneralH o sp ital o N anj ing M ilitary C omm and, PLA, N anj ing 210002, Ch ina Corresp onding author: YU Yap ing, E m ail: nyyp ing@ j lonline. com A bstract B leed ing and thrombotic d isorders po rtray oppo site ro le in pa tients w ith p lasm a ce ll dyscrasias( PCD . Labo ra tory signs o f acqu ired coagu lopath ies and acquired von W illebrand syndrom e are comm on, w hile c linically mi po rtant bleeding com plications are rare. Pa tientsw ith PCD are at increased r isk for venou s throm boembo lism ( VTE and the risk is furthe r enhanced in patients w ho re ce iv e tha lidom ide o r lenalidom ide, especia lly in com bina tion w ith dexam ethasone or chem otherapy. L ow mo lecu lar w e ight hepar in, w a r far in and asp irin hav e been show n to be effective in reducing the inc idence of VTE. K ey W ords P lasm a ce ll dyscrasia; M yelom a; A cquired von W illebrand syndrom e; V enou s thromboem bo lism; H aem orrhage ( p lasm a ce ll dyscras ia, PCD M ayo C lin ic, 869 MM B , , 7% , [ 3] ( MM ( W aldenstrom mac MM , WM rog lobu linem ia, WM ( pr mi ary am y lo id ( AL os is (M GUS PCD 17% 15% , MM 2% ~ [ 12] 33%