高原心脏病患者促血管内皮及平滑肌细胞生长因子-第三军医大学学报.docVIP

高原心脏病患者促血管内皮及平滑肌细胞1 李素芝2* 高钰琪1 陈彬3 郑必海2 黄学文2 杨定周2 左锋2 何兵2 1 第三军医大学高原军事医学系重庆400038 2 西藏军区总医院全军高山病防治中心拉萨850007 3 西藏军区总医院拉萨850007 摘要 目的 通过实验研究对高原心脏病患者血液中促血管内皮及平滑肌细胞生长因子的表达情况及其意义进行探讨。方法 对42例高原心脏病患者和40例高原健康者血液中促血管内皮生长肝细胞生长因子（HGF）血管内皮生长因子（VEGF）碱性成纤维细胞生长因子（bFGF）平滑肌细胞生长内皮素（ET-1）血小板源性生长因子（PDGF）成纤维母细胞生长因子（FGF）平滑肌细胞生长HGF、VEGF、bFGF及ET-1、PDGF、FGF血液中的表达均显著高于对照组（P0.05或P0.01）。高原心脏病患者均存在不同程度的右心改变及肺动脉高压，其右房（上下径/横径）、右室流出道、右室前后径、右室前壁厚度、肺动脉内径、肺动脉收缩压等测值均显著高于对照组（P0.01）。且高原心脏病患者HGF、VEGF、bFGF及ET-1、PDGF、FGF与其肺动脉收缩压呈显著的正相关。结论 高原心脏病患者血液中促血管内皮及平滑肌细胞平滑肌细胞Expression and Significance of Vascular Endothelial Growth Factors in Blood of Patients with High Altitude Heart Disease.1.Department of High Altitude Medicine, the Third Military Medical University, Chongqing, 400038.2. Center of high altitude medicine PLA, the military general hospital of Tibet, Lhasa, Tibet Autonomous Region 850007.3. Department of Cardiology, the military general hospital of Tibet 850007. Abstract Objective To investigate and discuss the expression and significance of vascular endothelial growth factors and vascular smooth muscle cell growth factors in blood of patients with high altitude heart disease through experimental study. Methods To detect the expression of vascular endothelial growth factors [hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF)] and vascular smooth muscle cell growth factors [endothelin-1 (ET-1), platelet-derived growth factor (PDGF), fibroblast growth factor (FGF)] in blood samples of 42 patients with high altitude heart disease and 40 healthy subjects in plateau as well as their color Doppler echocardiographies. Results The comparison of vascular endothelial growth factor and vascular smooth muscle cell growth factor in blood samples between the two groups of subjects indicated that the expression levels of HGF, VEGF, bFGF, ET-1, PDGF and FGF in those patients with high altitude disease were all higher that those in the con