维生素d缺乏与慢性阻塞性肺疾病-中华老年多器官疾病杂志.docVIP

·综 述· 维生素D缺乏与慢性阻塞性肺疾病 吴 洁，刘凌琳，唐利歆，龙 军，崔晓蓉，王笑梅，司良毅，李学军* （第三军医大学西南医院老年病科，重庆 400038） 【摘 要】维生素D对钙磷代谢的调节作用，以及对骨骼健康的影响已经众所周知。但是维生素D及其代谢物广泛的生理作用远不只是对骨骼的生物学效应,许多生理过程都直接或间接受维生素D调节。近年来，维生素D在骨质代谢和钙调节之外的作用越来越受到重视。慢性阻塞性肺疾病（COPD）是一种进行性呼吸功能减退的呼吸道疾病，在老年人群中发病率很高。有研究表明，COPD的严重程度与维生素D缺乏相关。本文的主要目的是提高对维生素D与COPD相关性的认识，并评估补充维生素D的潜在作用。 【关键词】维生素D；肺疾病, 慢性阻塞性 【中图分类号】 R977.24; R563.9 【文献标识码】 A 【DOI】 ? Correlation of vitamin D deficiency and chronic obstructive lung disease WU Jie, LIU Lin-Lin, TANG Li-Qing, LONG Jun, CUI Xiao-Rong, WANG Xiao-Mei, SI Liang-Yi, LI Xue-Jun* (Department of Gerontology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China) 【Abstract】 As we all know, vitamin D plays a vital role in the regulation of calcium and phosphate metabolism, and exerts essential effects on bone health. However, the wide-spread physiological roles of vitamin D and its metabolites are far beyond these well described effects in skeletal biology. Many physiological processes are directly or indirectly regulated by vitamin D. In recent years, more and more emphasis has been given to the roles of vitamin D in the other aspects besides bone metabolism and calcium homeostasis. Chronic obstructive lung disease (COPD) is a progressive functional disorder in the respiratory system with high prevalence in the older population. Evidence shows there is a correlation between the severity of COPD and vitamin D deficiency. This article aims to update the knowledge about the association of vitamin D with COPD, as well as to assess the potential role of vitamin D supplements in treatment of the disease. 【Key words】 vitamin D; pulmonary disease, chronic obstructive The work was supported by the Tackling Project of Science and Technology Research (Applied Technology) of Chongqing (cstc2012gg-yyjs10045). Corresponding author: LI Xue-Jun, E-mail: lixuejun3@126.com 维生素D对钙磷代谢的调节作用，以及对骨骼健康的影响已经众所周知。但是维生素D及其代谢物广泛的生理作用远不只是对骨骼的生物学效应，许多生理过程都直接或间接受维生素D调节。近年来，维生素D在骨质代谢和钙调节之外的作用