晚期非小胞肺癌一线治疗新进展.pdfVIP

# 1688 # , ×综述# 讲座Ø 黄艾弥, 韩宝惠 上海交通大学附属胸科医院肺内科, 上海200030 Advances of first- line treat ment in advanced non-small cell lung cancer H UA N G A i-mi, H A N Bao-hui Dep artment of P ulmonary M edicine, Shanghai Chest H osp ital Af f il iated to Shanghai iaotong University , Shanghai 200030, P. R. China = : 总结近期晚期非小细胞肺 [ ABSTRACT] OBJECTIVE: T o sum up the urrent advan es of 癌 一线治疗最新进展: 应用M edline f irst-line treatment in advan ed non-small ell lung an er . METH- 和 CKNI 期刊全文 据库系统, 以/ 晚期非 ODS: / Non-small ell lung an er, first-line treat ment, target thera- 小细胞肺癌一线治疗靶向治疗和维持治 py and maintenan e t herapy0 were sear hed as key words by Medline 疗0 为关键词, 搜索近期发表的大型临床研 and CNKI series full text detabase retrieval systems. Overall 29 究, 选择以Ó期研究为主的大型多中心随 pie es of papers were sele ted. RESULTS: The on ept in first-line 机临床研究共计纳入文献29 篇: t reatment is now experien ing a breakthrough as several trails hav- 随着多项新药临床试验的完成, 一线治疗 ing demonstrated the effi a y of new drugs. The hoi e of first-line 方案和治疗理念有了新的突破) ) ) 含铂两 t reatments is no longer limited in the several platinum-based dou- 药化疗模式不再是唯 一的一线治疗方法, blets. T arget therapy in addition to hemot herapy be omes one of 化疗联合靶向靶向单药正逐步成为 一线 t he options, as well as the single target drugs. Tumor histology 治疗的选择同时, 非小细胞肺癌根据不 sub-types is now a epted as an important role for t he orre t hoi e 同亚型选择不同的治疗已成为必然趋势 of t reatment . Gene mutat ion s reenings before target therapy not 而通过基因突变筛选患者接受靶向治疗不 only improve the effi ien y, but also avoid unne essary over-t reat- 仅提高了治疗的有效率, 也