通脉养心丸抗肾上腺素急性心律失常作用-天津中医药大学期刊编辑部.PDFVIP

第28 卷 第3 期 天津中医药大学学报 Vol．28 No．3 2009 年9 月 Journal of Tianjin University of Traditional Chinese Medicine Sep．2009 通脉养心丸抗肾上腺素急性心律失常作用 蔡小军，王 怡，胡利民，金烨成 摘要：[ 目的] 观察通脉养心丸在整体水平下的抗肾上腺素急性心律失常作用。[方法] 采用舌下静注盐酸肾 上腺素复制大鼠急性心律失常模型，观察通脉养心丸对心律失常潜伏期（min）、持续时间（min）、心律失常发生率 （％）以及注射肾上腺素后30 min 后血清超氧化物歧化酶（SOD）活力（kU/L）、丙二醛（MDA）（μmol/L）含量的影 响。 [结果] 静注肾上腺素可由自律性增高致室性心律失常。通脉养心丸能显著缩短盐酸肾上腺素所致心律失 常潜伏期及持续时间，降低心律失常发生率，并能提高血清SOD 活力，降低MDA 含量。 [结论] 通脉养心丸具有 抗肾上腺素所致大鼠急性心律失常的作用。 通脉养心丸；肾上腺素；心律失常 关键词： 中图分类号： 文献标识码： 文章编号： （ ） R241.2 A 1673－9043 2009 03－0133-03 Effect of tongmai yangxin pill in treating adrenaline-induced acute arrhythmia CAI Xiao-jun,WANG Yi, HU Li-min, et al (Department of Pharmacology and Toxicology, Research Center of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China) Abstract:[Objective] To observe the anti-arrhythmic action of Tongmai Yangxin Pill in adrenline-in- duced acute arrhythmia in vivo. [Methods] Based on the model of acute arrhythmia established by sub- lingual intravenous injection of adrenaline, the therapeutic effect of Tongmai Yangxin Pill in the laten- cy, duration and occurrence of arrhythmia was analyzed. Simultaneously, the activity of super oxide dis- mutase (SOD) and the content of malondialdehyde in serum were determined 30 minutes after intra- venous injection of adrenaline. [Results] Adrenaline induced arrhythmias due to increased automony. The latency and duration as well as the occurrence of adernaline-induced arrhythmia could be signifi- cantly reduced by preadministration with Tongmai Yangxin Pill. At the same time, the activity of serum