热休克蛋白与肺癌相关性的研究进展-中药新药与临床药理.docVIP

热休克蛋白与肺癌 刘海玲1,2，李 旦2，孙帅31. 同济大学生命科学与技术学院生物信息系，上海200092；2. 同济大学附属上海市肺科医院临床医学转化中心，上海200433；3. 广州万正药业有限公司新药研发中心，广东 广州 510663） 摘要热休克蛋白作为细胞抵抗外界刺激的产物，能够快速清除异常或变性蛋白而保护细胞免受损伤。近年研究发现肿瘤细胞中热休克蛋白的水平高于正常细胞，过度表达的热休克蛋白在肿瘤的发生发展过程中起重要作用，且影响肿瘤的治疗效果。本文概述了热休克蛋白与肺癌相关性的研究，用于肺癌治疗的热休克蛋白抑制剂研究现状，为研究肺癌发病机理及开发高效肺癌药物提供相关参考。 关键词: 热休克蛋白；应激反应；肺癌R285.5；R917 文献标志码：A 文章编号：1003-9783(2016) 01- doi: 10.3969/j.issn.1003-9783.2016.01. Research Advances of the Relevance about Heat Shock Proteins and Lung Cancer LIU Hailing1,2, LI Dan1, SUN Shuai3,*, XIE Peishan3 (1. Department of Bioinformatics, School of Life Science and Technology, Tongji University, Shanghai 200092, China; 2. Clinical Medicine Transformation Center，Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, China; 3. New Drug Research and Development Center, Guangzhou ImVin Pharmaceutical Co., Ltd, Guangzhou 510663 Guangdong, China） AbstractHeat shock proteins (HSPs), produced during the cells suffering external stimulation, can protect cells from being damaged by eliminating the abnormal or denatured proteins. Level of HSPs in cancer cells was found higher than those in normal ones in recent years, and the overexpressed HSPs played critical roles in the oncogenesis and the metastasis processes of cancer. The existence of excess HSPs was also an unfavorable factor for cancer therapy. This paper summarized recent studies referring to the correlation of HSPs and lung cancer and the application of HSP inhibitors in lung cancer therapy, and analyzed the feasibility of screening high efficient HSP inhibitors from Traditional Chinese Medicine. Our work may provide reference for studying the pathogenesis of lung cancer and developing high efficient drugs used for lung cancer. Keywords: Heat shock protein; stress response; lung cancer 热休克蛋白 (Heat shock protein, HSP) 又被称作热应激蛋白，广泛存在于原核和真核生物中，是生物进化的过程中具有高度保守性的一类蛋白，作为分子伴侣参与调控、维持细胞内多种蛋白的构象和功能，以帮助细胞在应激环境刺激下正常生长。大量研究发现，HSP在癌症发展的过程中起关键性作用，本文就近年来HSP在肺癌发展过程中的作用做一概述，并探讨其抑制剂的应用前景。 HSP及其功能 HSP最早发现