长春瑞滨加醛氢叶酸与大剂量氟尿嘧啶治疗晚期三阴性乳腺癌.docVIP

长春瑞滨加醛氢叶酸与大剂量氟尿嘧啶治疗晚期三阴性乳腺癌 　　[摘要] 目的 探讨长春瑞滨（NVB）加醛氢叶酸（CF）和大剂量氟尿嘧啶（5-FU）治疗晚期三阴性乳腺癌（TNBC）的疗效。 方法 选择2010年4月～2012年4月我院收治的35例晚期TNBC患者作为观察对象，给予NVB联合CF、大剂量5-FU进行治疗，观察患者化疗后的有效率、毒副反应、疾病进展时间（TTP）、1年生存率。 结果 治疗总有效率为74.29%，其中CR为5例，PR为21例，SD为5例，PD为4例，RP为26例。绝经前后有效率分别为40.00%、34.29%；浸润性导管癌和小叶癌有效率分别为42.85%、31.43%；转移灶单个和多个有效率分别为62.85%、8.57%；既往治疗包含紫杉类和不含紫杉类有效率均为37.14%。主要副作用有白细胞下降和口腔溃疡，其中白细胞下降总发生率为60.00%，口腔溃疡总发生率为74.29%，毒副反应大多为Ⅱ～Ⅲ级，在病患可承受范围内，疾病进展时间为（9.5±2.3）个月、1年生存率为（76.36±8.21）% 。 结论 NVB联合CF、大剂量5-FU治疗TNBC能提高有效率以及患者生存率，安全性较高，值得临床推广应用。 [关键词] TNBC；长春瑞滨；醛氢叶酸；氟尿嘧啶；晚期 [中图分类号] R575.2 [文献标识码] B [文章编号] 1673-9701（2013）34-0075-02 Changchun vinorelbine plus Leucovorin and high doses of fluorouracil in the treatment of advanced three negative breast cancer PANG Shiquan CHEN Yin YU Haiqing WU Jiang LIN Xiaohui ZHANG Lan Department of Oncology， the Peoples Hospital of Bao’an District， Shenzhen City， Guangdong Province， Shenzhen 515801，China [Abstract] Objective To investigate the effect of Changchun vinorelbine （NVB） plus leucovorin （CF） and high dose of 5-fluorouracil （5-FU） in the treatment of advanced three negative breast cancer （TNBC）. Methods A total of 35 patients with advanced TNBC from April 2010 to April 2012 in our hospital were selected as the study objects， and were given NVB in combination with CF， high dose 5-FU treatment， observed the efficiency， toxicity， disease time progress （TTP）， 1 year survival rate of patients after chemotherapy. Results The total effective rate was 74.29%， included 5 cases of CR， 21 cases of PR， 5 cases in SD， 4 cases in PD， 26 cases in RP. Menopause efficiency were 40.00%， 34.29%； invasive ductal and lobular carcinoma efficiency were 42.85%， 31.43%； metastasis of single and multiple efficiency were 62.85%， 8.57%； previous treatment contained taxane and not contained taxane effective rate was 37.14%. The main side effects were neutropenia and oral ulcer， the total occurrence rate of the decrease of white blood cells was 60.00%， oral ulcer o