2-氨基-5-溴-N,3-二甲基苯甲酰胺的电化学合成.pdf

Journal of Organic Chemistry Research 有机化学研究, 2014, 2, 18-22 Published Online June 2014 in Hans. /journal/jocr /10.12677/jocr.2014.22003 Electrochemical Synthesis of 2-Amino-5-Bromo-N,3-Dimethylbenzamide Lei Yang1,2, Bo Wang1,2, Hanxiao Zheng1,2, Bo Liu1,2, Jun You1,2, Mianyuan Wu1,2 1 College of Chemical and Environmental Engineering, Harbin University of Science and Technology, Harbin 2 Key Laboratory of Green Chemical Technology of College of Heilongjiang Province, Harbin Email: youjunjun@126.com th th nd Received: May 14 , 2014; revised: May 19 , 2014; accepted: May 22 , 2014 Copyright © 2014 by authors and Hans Publishers Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). /licenses/by/4.0/ Abstract In a single-chamber electrolytic cell, platinum as the anode and cathode, dilute sulfuric acid as the supporting electrolyte, 40wt.% hydrobromic acid in H2O as the reactant, 2-amino-N,3-dimethylbe- nzamide can be highly synthesized into 2-amino-5-bromo-N,3-dimethylbenzamide by the constant- current electrolysis under the voltage from 1.3 V to 2.0 V at room temperature. The optimum of reaction conditions is as follows: electrolyte is H SO , the volume of hydrogen bromide is 8 mL, 2 4 current density is 0.4 A, the reaction voltage is 1.32 - 1.65 V, product yield is 97.3% and the cur- rent efficiency was 88.3%. Keywords Electrochemical, 2-Amino-N,3-Dimethylbenzamide, 2-Amino-5-Bromo-N,3-Dimethylbenzamide 2-氨基-5-溴-N,3-二甲基苯甲酰胺的电化学合成 1,2 1,2 1,2 1,2 1,2 1,2 杨 雷 ，王 波 ，郑瀚骁 ，刘 波