组织芯片研究直肠癌中肿瘤相关基因的表达-上海伯豪生物技术有限公司.pdfVIP

肿瘤防治研究 20 10 年第 37 卷第 2 期 ·14 1 · DO I :10 . 397 1/ j . i ssn .. 20 10 . 02 . 005 组织芯片研究直肠癌中肿瘤相关基因的表达 1 1 2 3 4 4 4 4 林茂松 ,陈卫昌 ,黄俊星 ,杨 　斌 ,张宝峰 ,方 　静 ,周 　琼 ,胡 　莺 , 郜恒骏4 Expressions of Tumorassociated Genes by Immunohistochemical Staining to Tissue Mi croarray in Human Rectal Cancer L IN Maosong1 , C H EN Weichang1 , HU AN G J unxing2 , YAN G Bin3 , ZHAN G Baofeng4 , FAN G J ing4 , ZHOU Qiong4 , HU Ying4 , GAO Hengj un4 1. D ep a rtment of Gas t roente rology , F i rs t A f f i l i ate d H osp i t al , S oochow Uni ve rs i ty , S uz hou 2 15006 , Chi na; 2 . D ep a rtment of Oncology , Taiz hou Peop le ’s H osp i t al , 3 . D ep a rtment of Gas t roente rology ; 4 . N ational E ng i neeri ng Cente r For B iochip at S hang hai Corresp on d i ng A ut hor : C H E N Weichang , Em ai l : w eichang chen @126 . com Abstract :Objective 　 To st udy on t he exp ression s and clinical significance of t umora ssociat ed genes in human rect al cancer s and corresponding normal p aracancer rect al muco sa . Methods 　54 cases of human rect al cancer and 40 ca ses of p aracancer muco sa were collect ed and made into two ti ssue microarrays β which cont aining 54 dot s and 130 dot s resp ectively . Exp ression s of p 53 , cyclinD 1 , bcl2 , cat enin , c myc , COX2 and nm23h 1 p rot ein s were det ect ed by immunohi stochemical st aining to t hese ti ssue mi croarrays . Results 　Significant differences were found among rect al cancer s and benign p aracancer muco β ( sa