整合素lfa-1与其配体icam-1的生理功能及相关疾病.pdfVIP

中国细胞生物学学报 Chinese Journal of Cell Biology 2013, 35(8): 1225–1231 DOI: 10.11844/cjcb.2013.08.0083 整合素LFA-1与其配体ICAM-1的生理功能及相关疾病 * 李金丽 翟心慧 (河南师范大学生命科学学院, 新乡 453007) 摘要 整合素淋巴细胞功能相关抗原-1与其主要配体细胞间黏附分子-1的相互结合所介导 的细胞与细胞之间以及细胞与细胞外基质之间的黏附在免疫反应和炎症反应中都起重要作用。 LFA-1与ICAM-1对T淋巴细胞的活化和克隆增殖起着不可缺少的作用。LFA-1与ICAM-1还参与启 动免疫突触的形成、介导淋巴细胞的归巢等多种生理过程。另外, 风湿性关节炎、器官移植后发 生的急性排斥反应、冠心病和寻常型银屑病等许多疾病的发生发展都和LFA-1与ICAM-1的相互作 用有关。该文重点介绍了LFA-1与其配体ICAM-1参与的主要生理功能以及与此相关的几种疾病。 关键词 整合素; LFA-1; ICAM-1; 免疫突触; 淋巴细胞归巢; 类风湿性关节炎; 移植排斥 The Biological Functions of Integrin LFA-1 and Its Ligand ICAM-1 and the Related Diseases Li Jinli, Zhai Xinhui* (School of Life Science, Henan Normal University, Xin Xiang 453007, China) Abstract The binding of lymphocyte function-associated antigen-1 (LFA-1) to its major ligand interce- llular adhesion molecule-1 (ICAM-1) can mediate cell-cell and cell-extracellular matrix adhesion, which plays an important role in immune response and inflammation. The combination of LFA-1 and ICAM-1 is involved in many kinds of physical processes, including T lymphocyte activation and clonal proliferation, the initiation of the immune synapse’ formation, and mediation lymphocyte trafficking. In addition, it is related to the occurrence and develop- ment of many diseases, such as rheumatoid arthritis, organ transplantation acute rejection, coronary heart disease, and psoriasis vulgaris. In this review, we introduced the biological functions of LFA-1 and ICAM-1 and several dis- eases that associated with their interaction. Key words integrin; LFA-1; ICAM-1; the immune synapse; lymphocytes homing; rheumatoid arthritis; graft rejection 1