肺癌发生过程分子生物学机制的研究进展.pdfVIP

生物技术通报 BI OTECHN OLOG YB ULLETI N 2006 1 1 2 郭禹 付月君 1 2 ( , 030051; , 030006) : 肺癌已成为人类癌症死亡的主要原因之一综述近年来在肺癌发生发展 程中起重要作用且研究 较为成熟的癌基因抑癌基因及一些肺癌相关蛋白, 它们包括细胞周期素D1(Cyclin D1) 及抑癌基因p16肺癌转移 相关蛋白谷胱甘肽- S- 转移酶( GSTs) 癌基因Bcl-2ras 基因恶性肿瘤特异性生长因子(T SGF) 绒毛膜促性腺 激素(H CG) 粘蛋白8-羟基-脱氧鸟苷( 8-OH-dG) 具有磷酸酯酶活性的抑癌基因- TEN组织多肽特异性抗原 ( T S) , 通 介绍这些生物大分子在肺癌组织中上调或下调机制, 以期为肺癌的早期检测和治疗提供标志物 : 肺癌分子机制 研究进展 Research Progress in Molecular Mechanism of Pulmonary Carcinoma 1 2 Guo Yu Fu Yuejun 1 ( Dep artment of the environmental and secure engineering, North University of China, Taiyuan030051; 2 K ey Laboratory of Chemical Biology and olecular Engineering of inistry of Education, Shanxi University, Taiyuan030006) Abstract: ulmonary carcinoma is one of the leading causes of cancer death in mankind. In this study, w e re- view a series of novel genes or proteins, including of Cyclin D1, p16, metast asis-associat ed proteins, GSTs, Bcl-2, ras, T SGF, HCG, mucin genes, 8-OH-dG, T EN, T S et al. , which are up-regulat ed or down-regulated in lung carcinoma and may be involved in the development of it. The changes of these molecules may be considered as the bi- omarkers of early detection and therapy of human pulmonary carcinoma. Key w ords: ulmonary carcinoma Molecular mechanism Research progress 1 , , , , , , , WHO , 8, , , , 75 %, 2. 1细胞周期素D1( Cyclin D1) 及抑癌基因p16 的表