【精选】2011Advance in the synthesis of 3-alkyl flavones..pdfVIP

Bull. Chem. Soc. Ethiop. 2011, 25(3), 419-425. ISSN 10 11-3924 Printed in Ethiopia  2011 Chemical Society of Ethiopia SYNTHESIS OF SUBSTITUTED FLAVONE DERIVATIVES AS POTENT ANTIMICROBIAL AGENTS 1* 2 P. Venkatesan and T. Maruthavanan 1 Department of Chemistry, Mahendra Institute of Technology, Namakkal-637 503, India 2 Department of Chemistry, Sona College of Technology, Salem – 636 005, India (Received October 1, 2010; revised March 9, 2011) ABSTRACT.ABSTRAC The biological activity of flavone has been enhanced by introducing heteroaryl moiety in C-2 ABSTRACABSTRAC position of chromone derivatives. Thus, 2-(1H-Indol-3-yl)-4H-chromen-4-one derivatives (6a-e) and 2-(2- chloroquinolin-3-yl)-4H-chromen-4-one derivatives (7a-e) were synthesized from corresponding chalcone. They were structurally confirmed by analytical and spectral data and evaluated for their antimicrobial activities. The results showed that this skeletal framework exhibited marked potency as antimicrobial agents. KEY WORDS: KEY WORDS Chalcone, Flavone, Chromone, Antibacterial activity, Antifungal activity KEY WORDSKEY WORDS INTRODUCTION Flavone (2-phenylchromone) derivatives are naturally occurring heterocyclic compound belongs to the flavanoid group. It showed significant role in pharmaceutical effects [1] including leishmanicidal activity, oviposter stimulant phytoalexins, anti-HIV, vasodilator, antiviral, anti- oxidants, bactericidal, DNA cleavage, antiinflamatory, antimutagenic and anticancer. In general, the