【精选】A critical review of the roles of host lactoferrin in immunity.pdf

Biometals (2010) 23:365–376 DOI 10.1007/s10534-010-9297-1 A critical review of the roles of host lactoferrin in immunity • ¨ Dominique Legrand Joel Mazurier Received: 22 December 2009 / Accepted: 25 January 2010 / Published online: 9 February 2010 Springer Science+Business Media, LLC. 2010 Abstract Lactoferrin (Lf) is an essential element of immune cells, and thus to influence both adaptive and innate immunity, which refers to antigen-nonspecific innate immunities. The understanding of the roles of defense mechanisms that a host uses immediately or the host-expressed Lf in immunity comes from in within hours after exposure to an antigen. Following vivo and in vitro studies with exogenous Lf which, infection, Lf is released from neutrophils (PMNs) in although informative, rarely reflect the pathological, blood and inflamed tissues and, such as other soluble or non-pathological, conditions in the organism. In pattern-recognition receptors of the innate immunity, this review, the data from the literature will be Lf recognizes unique microbial molecules called critically analyzed in order to present a real picture of pathogen-associated molecular patterns (PAMPs): the regulatory roles of host Lf in immunity. LPS from the gram-negative cell wall and bacterial unmethylated CpG DNA. However, unlike classical Keywords Lactoferrin Immunity PAMPs receptors involved in the activation of Immunomodulation Immune cells immune cells, Lf may act either as a competitor for Lipopolysaccharides these receptors or as a partner molecule, depending on the physiological status of the organ