【精选】Cytokine-induced killer T cells kill immature dendritic cells by.pdfVIP

Cytokine-induced killer T cells kill immature dendritic cells by TCR-independent and perforin-dependent mechanisms Pramod S. Joshi,* Jin-Qing Liu,* Yin Wang,* Xing Chang,* John Richards,* Erika Assarsson,† Fu-Dong Shi,‡ Hans-Gustaf Ljunggren,† and Xue-Feng Bai*,1 *Department of Pathology and Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio, USA; †Center for Infectious Medicine, Department of Medicine, Karolinska Institute, F59, Karolinska University Hospital Huddinge, Stockholm, Sweden; and ‡Barrow Neurological Institute, NRC-428, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona, USA Abstract: Cytokine-induced killer (CIK) cells are host effects [6, 7]. Because of the important potentials of this ex vivo, expanded T cells with proven anticancer type of cell in cancer immunotherapy, it is important to learn activity in vitro and in vivo. However, their func- if these cells have other functional properties. It is also impor- tional properties with the exception of their cancer tant to understand molecular interactions that mediate or reg- cell-killing activity are largely unclear. Here, we ulate the effector functions of CIK T cells. show that CIK T cells recognize dendritic cells Dendritic cells (DC) have emerged as the major regulator in (DC), and although mature DC (mDC) induce CIK T cell response and NK cell activation [11–13]. Unlike other T cells to produce IFN-, immature DC (iDC) are cell types, DC have vastly different functions depending on killed selectively by them. Moreover, CIK T cell their stage of maturation. Thus, DC precursors may mediate activ