【精选】healthy volunteers 1.pdfVIP

Eur J Clin Pharmacol (1991) 41:561-567 ZuropeanJournalof CJ]~(~(~F1 @BG[x@Qc@e9 @ Springer-Verlag 1991 Inhibition of sucrose- and starch-induced glycaemic and hormonal responses by the z-glucosidase inhibitor emiglitate (BAY o 1248) in healthy volunteers B. Lembcke, U. R. F61sch, W. Gatzemeier, B. Liicke, R. Ebert, E. Siegel, and W. Creutzfeldt Division of Gastroenterology and Endocrinology, Department of Internal Medicine, University of G6ttingen, G6ttingen, FRG Received: July 10, 1990/Accepted in revised form: April 9, 1991 Summary. The absorbable deoxynojirimycin derivative glucose, serum insulin, serum GIR breath hydrogen, ad- emiglitate (BAY o 1248) is a potent competitive inhibitor verse effects of small intestinal o~-glucosidases in man. In two similar randomized, placebo-controlled, double blind investigations, the efficacy, duration of action and Intestinal c~-glucosidases are responsible for the assimi- tolerability of single doses of 10, 20 and 40 mg emiglitate lation of most dietary carbohydrates (starch, sucrose). have been assessed in healthy male volunteers after re- These enzymes mediate the terminal step of carbohydrate peated sucrose or maize-starch loads at 08.00, 12.00 and digestion (hydrolysis) at the surface of the brush border 17.00 h. membrane. Under physiological conditions, hydrolysis is Even at the