北京市清华大学XX年度生物化学1本科期末考试试卷.doc

清华大学XX年生物化学1本科期末考试试题 考试科目：生物化学 考试时间： 考试类型：期末试题 I.1: how many carbons does Arachidic acid have? (20 carbons)2: how many double bonds does Arachidonic acid have? (4 double bonds)3: list two advantages that fats have over sugars as stored fuels (more energy gram for gram; no hydration needed)4: where inside the cells are most of the phospholipids degraded (lysosomes)5: oligosaccharide head groups determine the blood type of an individual. How are they attached to the plasma membrane? (glycosphingolipids or lipids and surface proteins)6: list at least one genetic disease that could result from abnormal accumulation of membrane lipids (Tay-Sachs, Sandhoffa€?s, Fabrya€?s, Gauchera€?s, or Niemann-Pick diseases)7: list the three main eicosanoids that produced from arachidonic acid (prostaglandins; thromboxanes; and leukotrienes).8: list one NASID you know (aspirin, ibuprofen, or acetaminophen or meclofenamate)9: list two fat-soluble vitamins (A, D, E, K)10: which vitamin can be derived from beta-carotene (A).11: which year was the fluid mosaic model proposed? (1972)12: why the thickness of most biological membranes is thicker than 3nm, the standard thickness of lipid bilayer? ( due to association of proteins to the membrane and carbohydrates on the membrane)13: Please define the transition temperature of the lipid bilayer (the temperature above which the paracrystalline solid changes to fluid)14: If a membrane protein has its N-terminus exposed to the outside of the cell while its C-terminus resides in the cytosolic compartment, is it a type I transmembrane protein ? (yes).15: How can you predict if a protein has a transmembrane domain? (hydropathy or hydropathy index, or hydropathy plot).16: Name the two cell surface receptors that HIV use to enter cells (CCR5 and CD4).17: For the Na+ K+ ATPase, how many Na+ and K+ can it move across the membrane for the hydrolysis of one ATP (2 K+ in, 3 Na+ out).18: what drives F-type ATPases to synthesize ATP? (proton o