TOF方案诱导化疗口腔鳞癌的近期疗效及不良反应观察.docVIP

TOF方案诱导化疗口腔鳞癌的近期疗效及不良反应观察 　　【摘要】目的?u估多西他赛/奥沙利铂/氟尿嘧啶（TOF）方案对口腔鳞癌诱导化疗的近期疗效和安全性。 　　方法将69例口腔鳞癌患者随机分为两组，分别用TOF方案化疗36例及PF方案（顺铂/氟尿嘧啶）化疗33例。TOF方案：多西他塞，第1天75 mg/m2；奥沙利铂，第1天130 mg/m2；氟尿嘧啶，第1～5天750 mg/m2。2周后重复治疗1次，共进行2个疗程。PF方案：顺铂，第一天75 mg/m2；氟尿嘧啶，第1～5天750 mg/m2。2周后重复治疗1次，共进行2个疗程。于疗程结束后，对比评价两种方案的疗效及不良反应。 　　结果近期疗效观察：TOF方案组为CR 4例、PR 22例、SD 10例、PD 0例，总有效率（CR+PR）为72.2%；PF方案组为CR 0例、PR 16例、SD 15例、PD 2例，总有效率（CR+PR）为48.5%。两组总有效率比较差异有统计学意义（P0.05）。 　　结论TOF方案治疗口腔鳞癌近期疗效好，不良反应较低，在临床上值得推广应用。 　　【关键词】奥沙利铂；顺铂；氟尿嘧啶；口腔鳞癌 　　中图分类号：R739.85文献标识码：ADOI：10.3969/j.issn2017.01.005 　　Observation of short term efficacy and adverse effects of TOF regimen in the chemotherapy of oral squamous cell carcinoma 　　[HJ2][HJ] 　　LU Jianrong1，ZHANG Ling1，BAN Huajie1，WANG Daiyou2▲ 　　（1.Department of Stomatology，People’s Hospital of Yizhou City，Yizhou 546300；China；2.Department of Oral and Maxillofacial Surgery，Affiliated Stomatological Hospital of Guangxi Medical University，Nanning 530021，China） 　　[HJ2][HJ] 　　【Abstract】ObjectiveTo evaluate shorttime efficacy and safety of docetaxel/oxaliplatin/fluorouracil（TOF） regimen in the chemotherapy on oral squamous cell carcinoma（OSCC）. 　　Methods69 cases of OSCC were divided randomly into TOF group（n=36） and PF （cisplatin fluorouracil） group （n=33）.The TOF regimen：75 mg/m2 of docetaxel at d1，130 mg/m2 of oxaliplatin at d1 and 750 mg/m2 of fluorouracil from d1 to d5.Patients were treated again for one time two weeks later，with a total of two courses of treatment.The PF regimen：75 mg/m2 of cisplatin at d1，750 mg/m2 of fluorouracil from d1 to d5.Patients were treated again for one time two weeks later，with a total of two courses of treatment.After treatment，efficacy and adverse reactions of the two regimens were compared between the two treatment groups. 　　ResultsShorttime efficacy of TOF regimen showed 4 cases of complete response（CR），22 cases of partial response（PR），10 cases of stable disease（SD） and no progressive disease（PD） case，and overall response rate（