【精选】木本药用植物红豆杉研究的新进展.pdfVIP

2009, 22( 3): 439~ 445 Forest R esearch : 100 11498( 2009) 1* 2 3 邱德有 , 吴小红, 黄璐琦 ( 1. , , 100091; 2. , 100053; 3. , 100700 ) : , , , , , : ; ; ; ; ; ; : S795. 7 : A R ecen t A dvances in R esearch of the W oody M edicinal P lan t Taxus 1 2 3 QI U D eyou , W UX iaohong , H UAN G L uqi ( 1. Resear h Institute of Forestry, CAF; Key Laboratory ofT ree Breeding and Cultivation, State Forestry A dm inistration, Beijing 100091, China; 2. Guang AnM en Hospital, China A ademy of ChineseM edi al S ien es, Beij ing 100053, China; 3. Institute of Chinese M eteriaM edi a, China A ademy of ChineseM edi al S ien es, Beijing 100700, China) Abs tract: Taxus is an mi portant medi inal plant. Taxol ( generi nam e pa litaxel), a omp lex d iterpene am ide derived firstly from the Pa ifi yew (Taxus bre fio lia ) tree, has been approved as an mi portant pharma euti al drug. Th is antitumor and antileukem i agen t is effe tive against several an ers su h as ovarian and breast ar inomas. M ore re ently, taxol has show n prom ising resu lts in drugeluting oronary artery stents used in the treatment of diseased vas ulature. In th is paper, the re ent resear h progresses in Taxus ultivation, T axol hem i al sem i synthesis, Taxus ell ulture, endophyti fungus ulture andTaxolm etaboli engineering are surveyed. The prob lem s and future perspe tives for these resear h areas are dis ussed. K ey w ord s: Taxus; u ltivation; taxol; hem i al sem isyn thesis; ell u lture; endophyti fungus; metaboli engineering (Taxus sp. )( T