基于脑电超慢涨落信号探究心身疾病肝郁气滞证脑内神经递-环球中医药.PDFVIP

环球中医药2015年12月第8卷第12期摇 Global Traditional Chinese Medicine,December2015,Vol郾8,No郾12 摇1429 ·论著 · 基于脑电超慢涨落信号探究心身疾病肝郁 气滞证脑内神经递质特征 张成摇 赵志付摇 李健 揖摘要铱摇 目的摇 从脑内神经递质活性改变方面探究心身疾病肝郁气滞证的生物学标记。 方法 摇 本研究以“证病结合冶 “以方测证冶为研究方法,采用脑电信号非线性分析法———脑电超慢涨落分 析法为技术手段,把经柴胡疏肝散加减治疗2~8周后疗效为显效、临床痊愈的主证为肝郁气滞证的 患者治疗前的脑电超慢涨落图和健康人对照组的脑电超慢涨落图加以对照分析,比较两组脑内5鄄 羟色胺(5鄄hydroxytryptamine,5鄄HT)、多巴胺(dopamine,DA)、去甲肾上腺素(norepinephrine,NE)的激 活情况。 其中,肝郁气滞证患者27例,健康人对照组23例。 结果摇 与健康人对照组比较,肝郁气滞 证患者在C4脑区的5鄄HT激活水平下降(P0.05),在F4、C4脑区DA激活水平下降(P0.05),在 C3、P3脑区NE激活水平升高(P0.05)。结论摇 心身疾病肝郁气滞证在脑电超慢涨落图上有脑内 神经递质活性的规律性表现。 初步从脑电生理学和脑内神经递质活性改变方面,揭示出心身疾病 肝郁气滞证的生物学标记。 揖关键词铱摇 肝郁气滞证;摇 心身疾病;摇 脑电超慢涨落;摇 神经递质;摇 脑电信号 揖中图分类号铱摇 R542.2+2摇 揖文献标识码铱摇 A摇 doi:10郾3969/ j郾issn郾1674鄄1749郾2015郾12郾002 Research on the characteristics of cerebralneurotransmitters levels of ‘Stagnation of QI due to depression of the liver爷syndrome of psychosomatic diseases based on super encephalofluctuograph technology摇 ZHANG Cheng, ZHAO Zhi鄄fu, LI Jian. 摇 Guang爷Anmen Hospital, China Academy of Chinese Medical Sciences,Beijing 100053,China Corresponding author:ZHAOZhi鄄fu,E鄄mail:tcmzzf@ 揖Abstract铱摇 Objective摇 To explore the biological marker of ‘Stagnation of QI due to depression of the liver爷syndrome of psychosomatic diseasesfrom the aspect of brain neurotransmitters levels. Methods 摇 Syndromes arethecorewhilediseasesarethecomplement. Theaccuracyof SyndromeDifferentiationhas been verifyed by the curative effects of fixed traditional Chinese medicine (TCM) prescription from2 to 8 weeks. Each casewas summarized by curative effects according to efficacy standards of different diseases. Only the case of recovery and special effect could be enrolled in this study. Super Encephalofluctuograph Technology (SET,nonlinearanalysisof EEG)wasusedformeasuringbrainneurotransmitterslevels. Each case hasbeenmeasuredbySETbeforetreatme