呼吸机相关性肺炎病原学特点及耐药性.pdfVIP

2012 27 West China Medical Journal Vol.27 No.10 Oct. 2012 1471 RICUVAP , RICU VAP 2005 1 2011 12 RICU 48 h7 d 136 VAP RICU VAP 42.8% 136/31847.8% 65/136507 G− 74.8% 379/507G+ 10.3%52/507 14.9%76/507G− RICU VAP G− RICU A Analysis on the Characteristics and Drug Resistance of Ventilator-associated Pneumonia PathogensZHOU Zhong- wei, ZOU Jun. Department of Respiration, Sichuan Academy of Medical Sciences Sichuan Provincial Peoples Hospital, Chengdu, Sichuan 610072, P. R. China Abstract Objective To investigate the sources, distribution and drug resistance characteristics of ventilator- associated pneumonia (VAP) pathogens, so as to provide a scientific basis for better controlling of VAP in respiratory intensive care unit (RICU). Methods We retrospectively analyzed the clinical data, including distribution and drug resistance of the pathogens, of 318 patients treated in RICU from January 2007 to December 2011 with the mechanical ventilation time longer than 48 hours and hospital stay longer than 7 days. ResultsAmong those 318 patients in RICU, the incidence of VAP was 42.8% (136/318), and mortality was 47.8% (65/136). A total of 507 pathogens were isolated. Among those pathogens, gram-negative bacteria accounted for 74.8% (379/507), with pseudomonas aeruginosa ranking the fi rst, followed by acinetobacter baumannii and klebsiella pneumonia; gram-positive cocci accounted for 10.3% (52/507), with staphylococcus aureus being the most common; fungi acc