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1114
· · 现代生物医学进展 Progress in Modern Biomedicine Vol.11 NO.6 MAR.2011
·临床研究·
Expressions of HO-1 and VEGF in Patients of Sudden Cardiac Death
and Their Significances
1 2 2 2 2△
XU Wei-wei , YANG Yan -hua , JI Ping , WEI Xiao-ming , YU Jian -xian
( 1 The Affiliated Municip al Hosp ital of Qingdao University MedicalCollege, Qingdao 26602 1, China;
2 Dep artment of Pathology, Qingdao Municip al Hosp ital, Qingdao 2660 11, China)
ABSTRACT Obj ective: To investigate expression of the heme oxygenase-1 ( HO-1 and vascular endothelial growth factor (VEGF)
)
in the left ventricle in patients with sudden cardiac death (SCD). Methods: Immunohistochemistry and Simple PCI image analysis system
were used to detect the expressions of HO-1 and VEGF in 33 cases of SCD and 18 cases of non SCD (control group). Results: The ex-
pressions of HO-1( 155.090±8.957) and VEGF(121.020±10.927) in the myocardium of patients in SCD group were significantly higher
than those in control group (116.200±6.355, 84.207±4.402 ,all p0.05 . Conclusions: The high expression of HO-1 and VEGF may be
)
related with the sudden cardiac death to some extent.
Key words: Sudden cardiac death; HO-1; VEGF; Immunohistochemistry
Chinese Library Classification: R54 1 Document code: A
Article ID: 1673-6273(2011)06-1114-04
1.1 Materials
Introduction
Fifty-one heart s
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