鱼胆汁对兔肾功能的影响及其机制.pdfVIP

2012 27 West China Medical Journal Vol.27 No.6 Jun. 2012 841 1 1 1 1 2 2 3 GP n=19VI n=153 mL/kg0.3 mL/kg 1 5 h GP 20 min 5 h 5 h 5 h ScrK+ P 0.05HCO3− P 0.05VI ScrK+ GP GP pH A h e Inl uence of Fish Bile on the Renal Function of Rabbits and Preliminary Study on Its MechanismLUO Jing-chao 1 , 1 1 1 2 2 3 REN Long , HAN Yu-chen , Yan Qiao , MI Xu-hua , MA Xing-yi , YU Wei-ping . 1. Medical School of Southeast University, Nanjing, Jiangsu 210009, P. R. China; 2. Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China; 3. Department of Pathophysiology, Medical School of Southeast University, Nanjing, Jiangsu 210009, P. R. China Corresponding author: YU Wei-ping, E-mail: wpylg@ Abstract Objective To observe the infl uence of fi sh bile on the renal function of rabbits and to explore its mechanism. MethodsRabbits were randomly split into bile gastric-perfusion group (GP group, n=19) and bile venous-injection group ( group, n=15). A bile dose of 3 mL/kg and 0.3 mL/kg was given to rabbits in the above two groups respectively. The plasma indicators associated with renal function, water-electrolyte balance and acid-base balance were measured before and 1-5 hours after b