大学生长期配戴软性角膜接触镜对眼表的影响.docVIP

软性角膜接触镜长期及连续配戴对角结膜上皮的影响 郑洋 乔一平1 赵茂竹2 成阳洋1 1 四川省泸州医学院附属医院眼病中心，泸州，646000 2 四川省人民医院城东病区眼科,中国四川省成都市,610110 摘要 目的: 探讨软性角膜接触镜(soft contact lens,SCL)长期及延长配戴者角结膜上皮的变化。 方法 :正常对照组35例70眼病例组99例198眼采用角膜荧光素染色(fluorescein vital staining，FLS)、结膜印迹细胞学检查(conjunctival impression cytology，CIC)等检查方法。依据SCL戴镜年限将SCL戴镜者区分为5a组、5-10a组和＞10a组，共3组。依据SCL连续戴镜时间将SCL戴镜者区分为12h组、12-24h组和24h组，共3组。比较分析各组间的角膜荧光素染色、杯状细胞密度和结膜上皮鳞状化分级的差异。 结果: SCL戴镜各组FLS记分、杯状细胞密度与结膜上皮鳞状化分级与正常对照组间差异有统计学意义(p0.01)；5a组与5-10a组间，及5a组与＞10a组之间杯状细胞密度与结膜上皮鳞状化分级的差异有统计学意义(p0.01)；但5-10a组与＞10a组之间杯状细胞密度与结膜上皮鳞状化分级的差异无统计学意义(p0.05)。12h组与12-24h组之间，12h组与＞24h组之间FLS、杯状细胞密度与结膜上皮鳞状化分级的差异有统计学意义（p0.05）；12-24h组与＞24h组之间FLS、杯状细胞密度与结膜上皮鳞状化分级的差异无统计学意义（p0.05）, 结膜上皮鳞状化分级与FLS呈正相关(r=0.589，p0.001)；杯状细胞密度与FLS负相关(r=-0.351,p0.001)。 结论: 长期及延长配戴软性角膜接触镜会引起角膜上皮损伤和结膜上皮印迹细胞学改变，且戴镜时间越长，损害越大。 【关键词】软性角膜接触镜；角膜荧光染色；印迹细胞学；角膜 Effects of long-term extended contact lens wear on the corneal and conjunctival epithelial changes among university students Zheng Yang 1, LIAO Guang-rong1, Gan Zhong-lin 2, , Yi-ping Qiao1, Zhao-xia Huang1 (Ophthalmic Cener, the Affiliated Hospital of Luzhou Medical College，, Luzhou, 646000, China) 【Abstract】: bjective: To observe the difference of corneal and conjunctival epithelial changes between normal subjects and subjects with long-term soft contact lens(SCL) wear(5y) and subjects with prolonging SCL wear (12h) to probe the possible effects and mechanism on ocular surface with long-term and prolonging soft contact lens wear．Methods: In this study，fluorescein vital staining( FLS)，Conjunctival Imperssion Cytology(CIC) changes of long-term soft contact lens wearers were used. The study included 198 eyes of 99 soft contact lens wearers and 70eyes of 35 subjects as a control group. SCL wearers were divided into three groups according to the duration or wearing hours of each time of SCL wearing. The differences of FLS、goblet cell density（GCD）and grade of squamous metaplasia were analyzed．Results: There were statistically differences in FLS，goblet