冠状动脉性心脏病论文：p-选择素、胱抑素C水平与冠心病病变程度的相关性研究.docVIP

冠状动脉性心脏病论文：p-选择素、胱抑素C水平与冠心病病变程度的相关性研究 【中文摘要】通过对冠心病患者及造影正常者P-选择素(PS)和胱抑素C(Cys-C)水平的测定，探讨二者与冠心病病变程度的关系及临床意义。方法选择2011年4月至2011年8月我院心内科因胸痛住院的患者80例，男性39例，女性41例，年龄在51岁至69岁。收集患者一般资料(身高、体重、年龄、性别)，所有患者均行选择性冠状动脉造影，结果显示至少1支血管狭窄≥50％诊断为冠状动脉粥样硬化性心脏病，包括冠脉造影确诊冠心病者60例，其中单支病变组、双支病变组、三支病变组各20例，造影正常者20例作为对照组。所有入选对象均采集外周静脉血检测P-选择素、胱抑素C和血糖。分析P-选择素、胱抑素C与冠心病病变程度的关系，对P-选择素与胱抑素C进行单因素相关分析，P-选择素、胱抑素C分别与血糖进行单因素相关分析，对冠状动脉粥样硬化病变程度按照病变支数、Gensini积分标准评价，Gensini积分标准采用美国心脏病协会所定的冠状动脉血管图像积分分段评价标准。对P-选择素与Gensini积分进行单因素相关分析，对胱抑素C与Gensini积分进行单因素相关分析。结果(1)冠心病组P-选择素、胱抑素C水平较对照组明显增高，差异有统计学意义(P＜0.05)，二者在双支病变组和三支病变组显著高于单支病变组（P＜0.05），三支病变组与双支病变组无明显差别（P＞0.05）。(2)各组P-选择素水平与Gensini法评分呈正相关(r=0.552,P＜0.01)，胱抑素C水平与Gensini法评分呈正相关(r=0.453,P＜0.01)。(3)P-选择素和胱抑素C呈正相关(r=0.604,P＜0.05)。(4)P-选择素和血糖呈正相关(r=0.754,P＜0.05)，与体重指数呈正相关(r=0.537,P＜0.05)。(5)胱抑素C和血糖呈正相关(r=0.718,P＜0.05)，与体重指数呈正相关(r=0.608,P＜0.05)。结论(1)P-选择素和胱抑素C与冠心病病变程度密切相关。(2)P-选择素和胱抑素C参与冠心病的发生、发展过程，检测二者水平在冠心病的早期诊断中有重要的临床意义。 【英文摘要】P-selectin (PS) and cystatin C (Cys-C) levels of the patients with coronary artery disease and normal angiography outcomes were measured to investigate the relationship and clinical significance between P-selectin with Cystatin C levels and severity of coronary heart disease.Methods Between April and August,2011,80patients who received in-hospital care for chest pain,39cases of male,41cases of female,aged51-69years old.Gathered general information on patients(Height、Weight、Age、Sex).All patients underwent elective coronary arteriography,which showed no less than50%narrowing in one or more cardiac Vessels and were thereby confirmed to have artherosclerotic coronary heart disease.60patients were confirmed to have coronary heart disease by coronary angiography,there are respectively20cases in the single, double and three lesions group,20patients who are no results of coronary angiography were viewed as control group. All objects are collectived peripheral venous blood to detect P-selecting Cystatin C and blood glucose.We investigate the relationship be