精神分裂症论文：氯丙嗪、利培酮、阿立哌唑对精神分裂症病人血脂的影响.docVIP

精神分裂症论文：氯丙嗪、利培酮、阿立哌唑对精神分裂症病人血脂的影响 【中文摘要】:探讨3种抗精神病药物氯丙嗪、利培酮、阿立哌唑对精神分裂症病人血脂的影响,评价不同抗精神病药物的安全性,为合理运用抗精神病药物提供新的资料和临床经验。方法:选择147例单一应用抗精神病药物氯丙嗪、利培酮、阿立哌唑治疗满6个月的精神分裂症病人,分别于治疗前、治疗第1月末、治疗第3月末、治疗第6月末检测空腹血脂,包括甘油三酯(TG)、胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)。结果:①服用氯丙嗪治疗后3个月,TG、TC显著高于治疗前(P0.05);服用氯丙嗪治疗后6个月, TG、TC显著高于治疗前(P0.01)、治疗后1个月(P0.01)和治疗后3个月(P0.05,P0.01),HDL显著低于治疗前(P0.01)和治疗后1个月(P0.05),LDL显著高于治疗前(P0.05);②服用利培酮治疗后3个月, TG、TC显著高于治疗前(P0.05);服用利培酮治疗后6个月, TG、TC显著增高于治疗前(P0.01)、治疗后1个月(P0.01)和治疗后3个月(P0.05,P0.01),HDL显著低于治疗前(P0.01)和治疗后1个月(P0.05),LDL显著高于治疗前(P0.01)和治疗后1个月(P0.05);③服用阿立哌唑治疗前后,TG、TC、HDL和LDL无明显变化(P0.05);④服用氯丙嗪治疗后3个月,女性病人TC显著高于同期男性病人(P0.05);服用氯丙嗪治疗后6个月,女性病人TG、TC、LDL显著高于同期男性病人(P0.05);⑤服用利培酮治疗后6个月,女性病人TG、TC显著高于同期男性病人(P0.05);⑥服用阿立哌唑治疗前后,男女间血脂水平无明显变化(P0.05);⑦服用氯丙嗪治疗后3个月,高年龄组(41岁-60岁)LDL显著高于同期低年龄组(18岁-40岁)(P0.05);服用氯丙嗪治疗后6个月,高年龄组(41岁-60岁)TG、TC、LDL显著高于同期低年龄组(18岁-40岁)(P0.05);⑧服用利培酮治疗后6个月,高年龄组(41岁-60岁)TC显著高于同期低年龄组(18岁-40岁)(P0.05);⑨服用阿立哌唑治疗前后,高低年龄组间血脂水平无明显变化(P0.05)。结论:①长期氯丙嗪、利培酮治疗会升高精神分裂症病人血脂,尤其是41岁-60岁的女性病人;②阿立哌唑对精神分裂症病人血脂影响较小。 【英文摘要】: To estimate the effect of three antipsychotics (Chlorpromazine, Risperidone, Arpiprazole) on blood-lipid of patients with schizophrenia, to assess the safety of different antipsychotic drugs, and to provide new material and clinical experience for using antipsychotic drugs reasonably.Methods: One hundred and forty seven schizophrenics treated with only one of antipsychotic drugs (Chlorpromazine, Risperidone, Arpiprazole) at least 6-month were selected. Blood-lipid on an empty stomach was assessed prior and after 1-month, 3-month, 6-month treatment, including Triglyceride (TG), Total Cholesterol (TC), High Density Lipoprotein (HDL), and Low Density Lipoprotein (LDL).Results:①A fter 3 months treatment of Chlorpromazine, TG and TC levels of patients with schizophrenia was increased significantly than the level of prior treatment (P0.05); after 6 months treatment of Chlorpromazine, TG and TC levels of patients with schizophrenia was increased significantly than t