p63、ki-67在宫颈上皮内瘤变、鳞状细胞癌中的表达及意义.docVIP

精品论文 参考文献 p63、Ki-67在宫颈上皮内瘤变、鳞状细胞癌中的表达及意义 彭州同一医院 病理科 四川彭州 611930 【摘 要】目的：研究p63、 Ki-67在宫颈上皮内瘤变(CIN)、鳞状细胞癌中的表达及意义。方法：采用免疫组化分别检测宫颈上皮内瘤变30例、浸润性鳞状细胞癌67例中p63、Ki-67的表达，30例正常宫颈做对照。结果： p63的阳性率与CIN分级呈正比，但CIN与鳞状细胞癌阳性率差异无显著性。p63的表达与CIN分级无明显相关性。p63的表达与宫颈癌组织分化程度成正相关。Ki- 67 蛋白的表达在从子宫颈正常组织rarr;上皮内瘤变rarr;宫颈癌发展过程中呈逐渐上升的趋势。结论：p63在宫颈癌形成早期可能起促癌作用，且可能是鳞状上皮源性肿瘤的标记物。p63可能与细胞增殖有关。Ki- 67蛋白可能参与前宫颈癌的发生发展。因此，应用p63、Ki-67标记对宫颈癌前病变和宫颈癌诊断及判断预后有重要的临床意义。 【关键词】宫颈上皮内瘤变(CIN)；鳞状细胞癌；p63；Ki-67 【中图分类号】R737.33 【文献标识码】B 【文章编号】1764-8999（2015）7-0699-02 p63, ki - 67 in cervical intraepithelial neoplasia (CIN) and squamous cell carcinoma in the expression and significance. Wu Min (Department of Pathology, Pengzhou harmonious hospital, china) 【abstract】Objective: to study the p63, ki - 67 in cervical intraepithelial neoplasia (CIN) and squamous cell carcinoma in the expression and significance. Methods: immunohistochemical detected in 30 cases of cervical intraepithelial neoplasia and invasive squamous cell carcinoma in 67 cases of p63, the expression of Ki-67, 30 cases of normal cervix as control. Results: the positive rate of p63 and CIN grade higher than, but CIN there was no significant difference with the positive rate of squamous cell carcinoma. The expression of p63 and CIN grade has no obvious correlation. The expression of p63 and positively associated with the degree of cervical cancer tissue differentiation. Ki - 67 protein expression in normal tissue from the cervical to intraepithelial neoplasia, in the development of cervical cancer is gradually rising trend. Conclusion :p63 form promote cancer early may play a role in cervical cancer, and could be the original in the squamous tumor markers. p63 May be associated with cell proliferation.ki - 67 protein may participate in before the occurrence of cervical cancer development. Therefore, the application of p63, ki - 67 markers for cervical lesions and cervical cancer before the diagnosis and prognosis have important clinical signi