tct、scc-ag单一及联合检测在宫颈病变筛查中的应用价值分析.docVIP

精品论文 参考文献 TCT、SCC-Ag单一及联合检测在宫颈病变筛查中的应用价值分析 湖南省妇幼保健院 湖南长沙 410008 摘要：目的：观察和对比宫颈液基薄层细胞检测（TCT）、血清鳞状上皮细胞癌抗原（SCC-Ag）单一检测及两者联合检测宫颈病变筛查的临床价值。方法：选取2014年3月~2015年3月间我院收治的经TCT检测提示异常的妇女80例作为临床研究对象，对其进一步施行阴道镜病理活检和血清SCC-Ag检测，并以病理活检结果作为对照分析。观察和分析单纯TCT检测、单纯SCC-Ag检测及两者联合检测在宫颈病变筛查中的临床诊断价值。结果：单纯TCT检测的敏感度为75.0%，特异度为55.76%；单纯SCC-Ag检测的敏感度为60.71%，特异度为86.54%；两者联合检测的敏感度为53.57%，特异度为90.38%。单纯TCT检测和SCC-Ag检测的敏感度和特异度对比，（P＜0.05）差异均有统计学意义。两者联合检测的特异度为（90.38%），明显高于单纯TCT检测的特异度（65.38%），（P＜0.05）差异均有统计学意义。结论：与单一TCT检测和SCC-Ag检测相比，两者联合检测能够明显提高宫颈病变筛查的特异性，值得在临床上推广应用。 关键词：宫颈病变筛查；宫颈液基薄层细胞检测；鳞状上皮细胞癌抗原；诊断价值 【Abstract】Objective：To observe and compare liquid-based cervical cytology test（TCT），a single serum squamous cell carcinoma antigen（SCC-Ag）and the combination of both the clinical value of screening to detect cervical lesions.Methods：From March 2014 to March 2015 prompted by TCT detect abnormalities of Women in our hospital 80 cases of a clinical study，its further implementation of colposcopy biopsy and serum SCC-Ag detection and biopsy The results were compared as.TCT simple observation and analysis to detect，diagnose clinical value in screening of cervical lesions pure SCC-Ag detection and combined determination.Results：Pure TCT detection sensitivity of 75.0%，specific degrees of 55.76%；Pure SCC Ag - detection sensitivity of 60.71%，specific degrees of 86.54%；The joint detection sensitivity of 53.57%，specific degrees of 90.38%.Pure TCT detection and SCC Ag contrast sensitivity and specific degrees，（P lt; 0.05）difference had statistical significance.Both for joint detection of specific degrees（90.38%），significantly higher than the pure TCT detection of specific degrees（65.38%），（Plt; 0.05）difference had statistical significance.Conclusion：Compared with single TCT detection and SCC-Ag detection，combined detection can significantly improve both screening for cervical lesions specificity，worthy of clinical application. [Keywords]Cervical Dysplasia Screening；Diagnostic Value；Liquid-based Cervical Cytology