英国纽卡斯尔大学生理学().pptVIP

Lecture 22 Reabsorption in: - Loop of Henle - Distal convoluted tubule - Collecting Duct Urine concentration and dilution pH control Loop of Henle Loop of Henle Distal Convoluted Tubule Distal Convoluted Tubule Collecting Duct Collecting Duct Loop of Henle – Countercurrent Multiplier pH Control Summary * The Kidney Dr Georgina Carr georgina.carr@ncl.ac.uk School of Biomedical Sciences PSC1001 Physiology Loop of Henle Collecting duct DCT Thick Ascending Limb (TAL)-NaCl moves out -H2O stays From PCT Na+ Cl- Descending limb-H2O moves out -NaCl stays H2O To DCT ATP Na+ K+ Na+ 2Cl- K+,Cl- Na+ H+ K+ H2O TAL K+ Na+ Cl- H2O Lumen Interstitial space Loop of Henle ATP Na+ K+ Na+ 2Cl- K+,Cl- Na+ H+ K+ H2O TAL K+ Lumen Interstitial space ~25% filtered Na+ reabsorbed in TAL Na+/K+/2Cl- blocked by loop diuretics From PCT Distal Convoluted Tubule-NaCl moves out -H2O stays Na+ Cl- ATP Na+ Na+ Cl- Cl- H2O DCT K+ Lumen Interstitial space Na+ Cl- Distal Convoluted Tubule ATP Na+ Na+ Cl- Cl- H2O DCT K+ Lumen Interstitial space Na/Cl cotransporter blocked by thiazide diuretics ~8% filtered Na+ reabsorbed in the DCT and collecting duct From PCT Collecting duct-NaCl moves out -H2O reabsorption depends on ADH (lecture 23) -H+ and HCO3- movement Collecting Duct Na+ Cl- ATP Na+ Na+ Cl- Principal cell K+ Lumen Interstitial space K+ K+ Na+ Cl- Two types of cell -Principal cell -Intercalated cell (α and β) ATP Na+ Na+ Cl- Principal cell K+ Lumen Interstitial space K+ K+ Na+ reabsorbed via ENaCC ENaCC inhibited by amiloride Na+ reabsorption affected by aldosterone (Lecture 23) Regulation of H2O intake output important in maintaining osmolality and volume of fluids in various body compartments 2400 TOTAL 2400 TOTAL 100 Faeces 400 Respiration 400 Metabolism 400 Skin 500 Water in food 1500 Urine 1500 Drinking ml/day Output ml/day Intake Urine Concentration Dilution Regulation of H2O intake output important in maintaining osmolality