星点设计-效应面优化法优选复方止痛巴布剂基质-天津中草药杂志社.pdfVIP

中草药 Chinese Traditional and Herbal Drugs 第 44 卷 第 8 期 2013 年 4 月 ·985 · 星点设计-效应面优化法优选复方止痛巴布剂基质处方 1 2 2* 1 张洪兵 ，朱雪瑜 ，张铁军 ，李思思 1. 天津中医药大学，天津 300193 2. 天津药物研究院 释药技术与药物代谢动力学国家重点实验室，天津 300193 摘 要：目的 优选复方止痛巴布剂最佳基质处方。方法 采用单因素试验、星点设计-效应面优化法，以初黏力和外观（膏 体性状、残留性、皮肤追随性）为评价指标，对巴布剂基质处方进行优选，以确定最佳制备工艺。结果 优选基质配比为 NP-700-卡波姆 940-甘羟铝-微粉硅胶-甘油（5.34 ∶0.63 ∶0.2 ∶6 ∶30 ）。结论 优选所得基质黏着力适中，无残留，膏体性状、 皮肤追随性均较好，制备工艺良好。 关键词：复方止痛巴布剂；基质处方；星点设计；效应面优化法：单因素试验 中图分类号：R283.6 文献标志码：A 文章编号：0253 - 2670(2013)08 - 0985 - 04 DOI: 10.7501/j.issn.0253-2670.2013.08.013 Optimization of matrix recipe of Compound Analgesic Cataplasm by central composite design-response surface method 1 2 2 1 ZHANG Hong-bing , ZHU Xue-yu , ZHANG Tie-jun , LI Si-si 1. Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 2. State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China Abstract: Objective To optimize the matrix recipe of Compound Analgesic Cataplasm. Methods Taking the early adhesion and appearance (paste traits, residue, and skin adhesive ability) as evaluation indexes, the optimal matrix recipe of Compound Analgesic Cataplasm was optimized by single factor test and central composite design-response surface method, and the optimal preparation process was determined at the same time. Results The optimal ratio of the matrix is as follows: NP-700-carbopol 940-aluminium glycinate-silica-glycerin (5.34 ∶0.63 ∶0.2 ∶6 ∶30). Conclusion The optimal matrix has the moderate adhesion without residue but with better paste traits and skin adhesive ability under the ideal preparation technology. Key words: Compound Analgesic Cataplasm; matrix recipe; central composite design; response surface method; single fa