乳腺癌患者手术治疗前后血清CA153、CA125、Hcy和IL-8水平检测的临床意义.docVIP

精品论文 参考文献 乳腺癌患者手术治疗前后血清CA153、CA125、Hcy和IL-8水平检测的临床意义 王永东1 丁贤2 　　（1灌云县中医院 222200; 2连云港市东方医院 222042） 　　【摘要】目的：探讨了乳腺癌患者手术治疗前后血清CA153、CA125、Hcy和IL-8水平的变化及临床意义。方法：应用放射免疫分析法和免疫化学法对38例乳腺癌患者进行了手术治疗前后血清CA153、CA125、Hcy和IL-8水平检测，并与35个正常健康人做比较。结果：乳腺癌患者在手术治疗前血清CA153、CA125、Hcy和IL-8水平均非常显著地高于正常人组（P＜0.05），手术治疗3个月后则与正常人比较无显著性差异（P＞0.05），血清CA153水平与CA125、IL-8水平呈显著正相关（r=0.6028、0.5722、0.4986，P＜0.01）结论：检测乳腺癌患者手术治疗前后血清CA153、CA125、Hcy和IL-8水平的变化对观察病情和预后判定均具有重要的临床价值。 　　【关键词】乳腺癌 糖类抗原-153 糖???抗原-125 同型半胱氨酸 白细胞介素-8 　　【中图分类号】R737.9 【文献标识码】A 【文章编号】2095-1752（2014）11-0260-02 　　 Clinical significance of lueasurement of changes of serum CA153、CA125、Hcy and IL-8 levels after operation in patients with Breast cancer. Wang yong dong1，ding xian2, 　　 1. Jiang Su Guan Yun county traditional Chinese medicine 2. Lian yun gang city east hospital. 　　【Abstract】Objective: to explore the clinical significance of changes of serum CA153、CA125、Hcy and IL-8 levels after operation in patients with Breast cancer. 　　Methods: serum CA153、CA125、IL-8 (with RIA) serum Hcy（with immune chemistry）levels were determined in 38 patients with Breast cancer and 35 controls . 　　Result: Before operation serum CA153、CA125、Hcy and IL-8 levels were significantly higher than those in controls (P＜0.01) .After operation for 3 months, the levels were not significantly different from those in controls (P＞0.05). serum CA153 levels were positively correlated with serum CA125、Hcy、IL-8 levels(r=0.6028、0.5722、0.4986，P＜0.01). 　　Conclusions：Detection of serum CA153、CA125、Hcy and IL-8 levels after operation might be of prognostic importance in patients with Breast cancer. 　　【Key words】Breast cancer carbohydrate antigen-153(CA153) carbohydrate antigen-125(CA125) homocysteine (Hcy) nterleukin-8 (IL-8) 　　乳腺癌为女性常见的恶性肿瘤，发病率占各种恶性肿瘤的7％-10％，严重地危害女性的身体健康。CA153为诊断乳腺癌最为常用的肿瘤标志物[1]，CA125为卵巢癌常用的肿瘤标志物[2]，Hcy水平检测对消化系统肿瘤诊断有一定的临床价值[3]。IL-8与恶性肿瘤的关系十分密切[4]。本文报告乳腺癌患者手术治疗前后血清CA153、CA125、Hcy和IL-8水平的