伊班膦酸钠和帕米膦酸二钠治疗骨转移癌疼痛的临床观察.docVIP

精品论文 参考文献 伊班膦酸钠和帕米膦酸二钠治疗骨转移癌疼痛的临床观察 杨钰贤 江艺 林丹霞 方玫玫 郑瑾 陈志明 　　（汕头大学医学院附属肿瘤医院肿瘤内科 广东汕头 515031) 　　【摘要】目的 评价伊班膦酸钠和帕米膦酸二钠治疗骨转移癌疼痛的临床疗效和安全性。方法 62例患者随机分为伊班膦酸钠组和帕米膦酸二钠组各31例，伊斑膦酸钠组给予伊班膦酸钠治疗，帕米膦酸二钠组给予帕米膦酸二钠治疗，2组均用药2～6个周期。观察2组用药后止痛效果、骨修复、活动能力及不良反应发生情况。结果 用药第14天时伊班膦酸钠组临床获益率为87.1％高于帕米膦酸二钠组的64.5％，差异有统计学意义(Plt;0.05)；治疗56d伊班膦酸钠组临床获益率为90.3％，帕米膦酸二钠组为83.8％，差异无统计学意义(Pgt;0.05)。2组主要不良反应主要为发热、乏力，严重程度与骨质损害呈相关。结论 伊班膦酸钠治疗骨转移癌疼痛疗效略优于帕米膦酸二钠，两者不良反应均较轻，均有良好的耐受性，值得临床推广应用。 　　【关键词】伊班磷酸钠 帕米膦酸二钠 骨转移癌 疗效 　　【中图分类号】R969.4 【文献标识码】A 【文章编号】1672-5085（2014）08-0071-02 　　Clinical observation of Ibandronate and Pamidronate in Treatment of Pain Caused 　　by Bone Metastasis 　　YANG Yu-xian , JIANG Yi , LIN Dan-xia, FANG Mei-mei, ZHENG-Jin ,CHEN Zhi-ming（Dept.of Oncology, Tumor Hospital of Shantou University Medical College, Shantou Guangdong 515031,China） 　　【Abstract】 0bjective To evaluate the clinical therapeutic effect and safeness of ibandronate and pamidronate in treating pain caused by bone metastasis．Methods 62 cases were randomly divided into ibandronate group and pamidronate group，31 cases of each．The ibandronate group was treated with ibandronate，while the pamidronate group was treated with．Both groups were treated for 2 to 6 cylces．Observed 2 grouprsquo;s odynolysis effect，situations of bone reparation，activity ability and adverse reaction．Results On the 14th day of administration，the clinical benefit rate of ibandronate group was 87.1％ higher than 64.5％ of the pamidronate group，and the difference was statistically significant(Plt;0.05).On the 56th day of administration．the clinical benefit rate of ibandronate group was 90.3％ higher than 83.8％ of the pamidronate group，and the difference was of no statistical significance(Pgt;0.05)．The main adverse reactions of 2 groups were fewer and weakness，and the severity had positive correlation with bone damage．Conclusion Ibandronate has good curative effects above pamidronate in treating pain c