双歧杆菌活菌胶囊联合质子泵抑制剂三联疗法治疗幽门螺杆菌阳性消化性溃疡的临床分析.docVIP

精品论文 参考文献 双歧杆菌活菌胶囊联合质子泵抑制剂三联疗法治疗幽门螺杆菌阳性消化性溃疡的临床分析 潘红 　　（四川省大邑县人民医院 611330） 　　【摘 要】目的：分析双歧杆菌活菌胶囊联合质子泵抑制剂（PPI）三联疗法治疗幽门螺杆菌（HP）阳性消化性溃疡的临床疗效。方法：将我院收治的86例HP阳性消化性溃疡患者随机分为观察组43例和对照组43例。对照组患者行常规PPI三联疗法治疗， 观察组患者行双歧杆菌活菌胶囊联合PPI三联疗法治疗。评价2组患者的临床治疗效果，统计患者的HP根除率及不良反应的发生率，并检测2组患者治疗前后血浆胃动素（MTL）和生长抑素（SS）的表达水平。结果：观察组患者临床治疗的总有效率为93.02%，对照组为81.39%，2组比较，差异具有统计学意义（P＜0.05）。治疗后4周，观察组患者的HP根除率为83.72%，对照组为65.12%，2组比较，差异具有统计学意义（P＜0.05）。同时，观察组患者不良反应的总发生率为23.26%，对照组为46.51%，2组比较，差异具有统计学意义（P＜0.05）。治疗后，观察组患者的平均MTL指标水平低于对照组（P＜0.05），平均SS指标水平高于对照组（P＜0.05）。结论：在常规PPI三联疗法治疗的基础上联用双歧杆菌活菌胶囊可有效提高幽门螺杆菌阳性消化性溃疡的临床疗效及HP根除率，且能有效降低药物不良反应的发生率，值得临床推广应用。 　　【关键词】消化性溃疡；幽门螺杆菌；质子泵抑制剂三联疗法；双歧杆菌活菌 　　【中图分类号】R656.6+2 【文献标识码】B 【文章编号】1003-5028（2015）7-0135-02 　　Analysis of bifidobacterium viable capsule combined proton pump inhibitors triple therapy in the treatment of helicobacter pylori positive peptic ulcer clinical curative effect 　　【Abstract】objective: to analyze the bifidobacterium viable capsule combined proton pump inhibitors (PPI) triple therapy in the treatment of helicobacter pylori (HP) positive clinical effect of peptic ulcer. Methods: our hospitalrsquo;s 86 cases of HP positive patients with peptic ulcer were randomly divided into the observation group (43 cases) and the control group (43 cases). The control group patients were treated by regular PPI triple therapy, the observation group patients were treated by bifidobacterium viable capsule combined PPI triple therapy. 2 groups of patients with the clinical treatment effect were evaluated, the HP eradicate rate of the patients and the incidence of adverse reactions was statistics, before and after treatment, 2 groups of patients with gastric dynamic element of plasma (MTL) and somatostatin (SS) expression level were detected. Results: observation group of patients with clinical treatment the total effective rate was 93.02%, control group was 81.39%, the comparison of two groups, statistically significant difference (P lt; 0.05). 4 weeks after treatment, th