50例小儿抽动秽语综合征的临床特征和治疗.docVIP

精品论文 参考文献 50例小儿抽动秽语综合征的临床特征和治疗 王燕1 史积善2 陈小霞2 陈飞龙2 张灵恩3 1 上海市徐汇区中心医院(上海 200127) 2上海鸿慈儿童医院 3复旦大学附属儿科医院 【摘要】 目的 探讨和分析抽动秽语综合征的临床特征和治疗；方法 应用韦氏（Wechsler）智力量表对患儿智商进行评估， 同时，采取病例对照方式研究了硫必利和综合治疗对抽动秽语综合征病情缓解的影响，其中，50例病人分为两组，一是硫必利治疗组（n=24）二是综合治疗组（n=26）；结果 智商测试显示抽动秽语综合征患儿的IQ值处于边缘或智力落后；硫必利治疗组的病情有效率约为50%，而综合治疗组为90%以上，两组相比有显著性差异；结论 抽动秽语综合征的患儿智商偏低下，这是一个严重危害儿童身心健康的社会问题；积极采取综合治疗手段治疗抽动秽语综合症，对于提高患儿的学习能力和智力水平，以及重塑人格，重新回归社会有着积极的意义。 【关键词】抽动秽语综合征临床特征智商 硫必利 综合治疗 ［中图分类号］R725［文献标识码］A［文章编号］1810－5734(2012)2-01-03 Analysis of the Clinical Features and treatment of 50 Cases Tourette Syndrome English 【Abstract】 Objective analysis of the clinical features and treatment of Tourette syndrome; MethodsWechsler screening was used for IQ scale; a case-control study of tiapride and combined treatment was used to compare the influence on outcoming of Tourette syndrome，50 patients divided into two groups, one tiapride treatment group (n = 24), second, the combined treatment group (n = 26); Resultsin children with Tourettes syndrome, IQ test scale display borderline or mental retardation value at the edge; the condition improved rate for tiapride treatment group was about 50%, and it is over 90% for the combined treatment group (n = 26), which was significantly difference compared the two groups; Conclusionchildren with Tourette syndrome have low intelligence, it is a serious social problems harm to childrens physical and mental health; adoption actively onthe combined treatment is for improving childrens learning ability and intelligence, also, ithas a positive meaning to remodeling childrenrsquo;s personality and help them re-returningto society.  【Key Words】 Tourette Syndrome, Clinical Features, IQ, tiapride, combined treatment 抽动秽语综合征(tics-coprolalia syndrome)又称Tourette综合征(Tourettersquo;syndrome，TS)，法国神经病学家Georges GillesdeLa Tourette早在1885年首先详细描述该综合征。 本综合征是以不自主的，突然的，多发性抽动，以及在抽动的同时伴有暴发性发声和秽语为主要表现的抽动障碍。男性多见,男女之比为3∶1～9∶1, 90%以上于2～12岁之间起病［１］。美国报道的年发病率为45/10万，而国内报道一般人群其发病率为1-12%, 近年来，发病率