人甲状腺离体射频消融的试验观察-迈德医疗科技上海有限公司.pdfVIP

520 中国耳鼻咽喉头颈外科 / 2014年10月，第21卷，第10期 人甲状腺离体射频消融的实验观察 1 1 1 1 2 石文媛，朱强，马腾，胡敏霞，陈晓红 首都医科大学附属北京同仁医院 1 超声诊断科，2 耳鼻咽喉头颈外科，耳鼻咽喉头颈科学教育部重点实验室（首都医科大学）， 北京　100730 [摘　要]　目的　对人离体甲状腺组织进行射频消融 University), Ministry of Education, Beijing, 100730, China （radiofrequency ablation ，RFA ），了解消融形态、大小和 Corresponding author：ZHU Qiang(Email ：qzhu@263.net) 消融区域的病理变化。 　采用单针双极式电极，设 [ABSTRACT] OBJECTIVE　To obtain parameters 方法 　 定5 W功率，RFA人离体甲状腺新鲜标本18块，观察消融 of radiofrequency ablation (RFA) on human thyroid and 形态，测量消融区大小（长径和宽径），记录消融时间，观 observe the pathologic changes of the ablated area in vitro. 察消融区病理改变。 　消融区长径0.7 ～1.5 cm，平均 METHODS　RFA was performed in 18 pieces of the 结果 （1.15±0.21）cm ，宽径0.4 ～0.9 cm ，平均（0.64 ±0.14）cm。 resected human thyroid tissue in vitro with 5 W power output. 消融时间8 ～88 s ，平均（50.5 ±20.0 ）s。肉眼观察显示各标 The shape and size (long and short axis dimensions) of ablated 本消融区形态稳定一致，呈椭圆形，剖面上从中心向外周依 area, RFA duration, and pathologic changes were observed. 次是针道区、消融区、消融周围区。镜下显示消融区发生凝 RESULTS　The long and short axes of the ablated area as 固性坏死，细胞结构被破坏，核减少和核变形明显。结论 above were 0.7 cm to 1.5 cm (mean 1.15 ±0.21) cm and 0.4 cm 采用低功率（5W）单针双极式电极RFA人甲状腺离体组织， to 0.9 cm (mean 0.64 ±0.14) cm. The ablation duration were 8 可获得椭圆形的凝固性坏死的消融区。 s to 88s (mean 50.5 ±20.0) s. The ablation area was excellent [关键词]　甲状腺；甲状腺结节；射频消融 uniformity and its shape was spherical. Three distinct zones of the ablated area were identified as an electrode Experimental observation of radiofrequency ablation on path, a ablation zone, and a region near to the ablated zone. human thyroid in vitro Microscopically, coagulation necrosis and cellular des