麻省理工学院 生物材料课程 Lecture 10 Surface Modification of Biomaterials(PartII).pdf

3.051J/20.340J 1 Lecture 10: Surface Modification of Biomaterials (Part II) Surface Modification Methods A. Plasma Treatments Plasmas: ionized gases (ions, electrons, free radicals, atoms, molecules) + created by ion/electron impact under applied E-field: A + e → A + 2e Uses 1. surface etching ¾employs inert gases (e.g., Ar) ¾purposes: remove impurities, increase roughness 2. surface reactions ¾crosslink polymer surfaces modify transport properties, reduce surface mobility ¾generate surface functional groups ↑ or ↓γ1, create reactive surfaces O , CO , CO: -C-O-, -C=O, -O-C=O, -C-O-O 2 2 N , NO , NO (nitric oxide): -C-N, -C=N, -C≡N (plus above) 2 2 NH (ammonia): -NH, -NH (plus above) 3 2 CF , C F (hexafluorethane): -CF, -CF , -CF 4 2 6 2 3 3.051J/20.340J 2 Drawbacks: a. ill-defined surface chemistries b. reconstruction nullifies treatment θa O2-plasma treated HDPE - - - 90 PDMS — 40 48 time (hrs) 3. Coating Depositions ¾graft polymerized layers plasma + monomer ⇒ radically-polymerized surface layer hydrophilic monomers: hydroxyethyl methacrylate (HEMA), N- vinyl-2-pyrollidone (NVP), methacrylic acid (MAA), acrylamide (AAm), etc. H2C=CH H2C=CH