帕金森病患者的睡眠障碍研究.docVIP

精品论文 参考文献 帕金森病患者的睡眠障碍研究 金勇 潘小平 李泽 郑浩（惠州市中心人民医院 516001） 【中图分类号】R742.5【文献标识码】A【文章编号】1672-5085（2012）14-0010-02 【摘要】目的 探讨帕金森病（Parkinsonrsquo;s disease, PD）患者的多导睡眠图（polysomnography, PSG）特点。方法 对21名PD患者及21名健康对照者进行全夜PSG监测，分析患者睡眠结构、进程参数。结果 PD组总睡眠时间、睡眠效率、总睡眠期变化、S2(min)、S3+S4(min)、REM(min)、REM(%)均较对照组降低或缩短（Plt;0.05），入睡后觉醒时间、S1(min)、S1(%)增加或延长（Plt;0.05）。 结论 PD患者睡眠浅、时间短、效率低、转换多,慢波及REM睡眠少。 【关键词】帕金森病 睡眠障碍 多导睡眠图 A Study into the sleep disorder of Parkinsons Disease Jin yong, Pan xiao ping, Li ze, Zheng hao (HuiZhou Municipal Central Hospital, HuiZhou 516001) 【Abstract】Objective To analyze the characteristics of the all night polysomnography (PSG) of Parkinsonrsquo;s disease (PD) patients. Methods The monitoring of the all night PSG was performed respectively in the Twenty-one PD patients and the Twenty-one non-PD patients .The characteristics of the PD patients including sleep architecture, process parameter and abnormal behaviors of sleep were analyzed. Results The total sleep time, sleep efficiency, number of stage shifts, S2(min), S3+S4(min), REM(min), REM(%) in PD group were lowered or shortened than controls（Plt;0.05）; the awake time after sleep, S1(min), S1(%) in PD group were increased or prolonged than controls（Plt;0.05）.Conclusions The PD patients had characteristics of short total sleep time, low sleep latency, many number of stage shifts, little slow wave sleep and REM sleep, somnolence increased etc. 【Key Words】Parkinsonrsquo;s disease sleep disorder polysomnography PD患者睡眠障碍多见，已严重影响患者生活质量，需引起临床足够重视。本文就对21名PD患者及21名健康对照者进行全夜PSG监测，分析比较两组的睡眠特点。现报道如下。 1 资料与方法 1.1研究对象 选自近期在我院门诊及住院的21例PD患者为PD组，其中男性10例，女性11例，平均年龄 (69.95plusmn;8.99)岁，起病平均年龄(65.19plusmn;9.26)岁，平均病程(4.76plusmn;2.83)年；PD评定量表一运动检查(the change in unified Parkinsonrsquo;s disease rating scale-III , UPDRS-III)评分 (19.00plusmn;8.05)分；Hamp;Y分期(Hoehn-Yahr stages) I期2例，II期10例，III期7例，IV期2例。PD组睡眠评价除PSG外还采用匹兹堡睡眠质量指数（Pittsburgh sleep quality index, PQSI）及爱泼沃斯思睡量表（Epworth sleepines