Alpha lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy英文电子书.pdf

Experimental Neurology 214 (2008) 276–284 Contents lists available at ScienceDirect Experimental Neurology journal homepage: www. elsevier. com/ locate/ yexnr Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy Giorgia Melli a,⁎, Michela Taiana a, Francesca Camozzi a, Daniela Triolo c, Paola Podini c, Angelo Quattrini c, Franco Taroni b, Giuseppe Lauria a a Neuromuscular Diseases Unit, IRCCS Foundation Neurological Institute “Carlo Besta”, Via Celoria, 11 20133, Milan, Italy b Biochemistry and Genetics Units, IRCCS Foundation Neurological Institute “Carlo Besta”, Milan, Italy c San Raffaele Vita e Salute University, Milan, Italy a r t i c l e i n f o a b s t r a c t Article history: The study investigates if alpha-lipoic acid is neuroprotective against chemotherapy induced neurotoxicity, if Received 27 June 2008 mitochondrial damage plays a critical role in toxic neurodegenerative cascade, and if neuroprotective effects Revised 8 August 2008 of alpha-lipoic acid depend on mitochondria protection. Accepted 21 August 2008 We used an in vitro model of chemotherapy induced peripheral neuropathy that closely mimic the in vivo Available online 9 September 2008 condition by exposing primary cultures of dorsal root ganglion (DRG) sensory neurons to paclitaxel and cisplatin, two widely used and highly effective chemotherapeutic drug