急性心肌梗死患者血脂改变及相关性分析.docVIP

精品论文 参考文献 急性心肌梗死患者血脂改变及相关性分析 许莉 许明涛 (内蒙古医科大学附属人民医院 内蒙古呼和浩特 010020) 【摘要】目的 研究多种血脂成份预测急性心肌梗死(AMI)的风险的可行性。方法 采用随机抽样调查住院病历资料的方式，选取80例AMI患者(AMI组)、40例以胸痛为主要临床表现而未发生AMI的冠心病患者(胸痛组)和年龄性别相匹配的非冠心病患者(对照组)的部分血生化指标以及病史等进行研究，AMI组中ST段抬高性心肌梗死，非ST段抬高性心肌梗死各40名。结果 (1)与对照组相比，ST段抬高性心肌梗死和非ST段抬高性心肌梗死在TC|、LDL和HDL水平上有显著性差异，但是与胸痛组相比并没有显著性差异。(2)血清TG水平在各组中没有显著性差异。(3)与对照组相比，ST段抬高性心肌梗死和非ST段抬高性心肌梗死的超敏反应蛋白(hsCRP)有显著性升高。(4)血清hsCRP与HDLC显著负相关，但是hsCRP与TC、LDL和TG没有相关性。结论 降低血清TC不能降低AMI的风险。增加HDLC和hsCRP能显著增加AMI发作的风险。HDLC和hsCRP可能是预测高危个体以及AMI患者预后的有用的标志物。 【关键词】 急性心肌梗死 血脂 生物标志物 【中图分类号】R54 【文献标识码】A 【文章编号】2095-1752（2013）14-0111-02 The Analysis of Lipid Profile of Patients with Acute Myocardial Infarction and its Correlation Xu Li, Xu Mingtao 【Abstract】 0bjective To study the biomarker potential of using various lipids fractions for predicting risk of acute myocardial infarction. Methods By refering to medical records，this study researched the blood lipids changes in 120 patients (as the studying group) and 40 normal people (as the control group). Results There were significant decreases in TC, LDLC and HDLC levels in both STEMI and NSTEMI patients as compared to normal subjects; however, patients with chest pain did not show any significant change in these lipids. Serum TG levels did not differ significantly among the study groups. There were significant increases in serum high-sensitive C-reactive protein (hs-CRP) levels in STEMI and NSTEMI patients, as compared to control group. Serum hs-CRP showed significant inverse correlation with HDLC; however, hs-CRP was not correlated with TC, LDLC, and TG. Conclusion Our findings suggest that reduction in serum TC does not prevent the risk of AMI, whereas a decrease in serum HDL and increase in hs-CRP strongly predisposes the risky individuals to an AMI event. We emphasize the importance of HDL and CRP measurements for the assessment of a combined lipid-inflammation risk factor that could be a useful predic