探讨小儿先天性心脏病合并心力衰竭患者外周血中C—反应蛋白及脑钠肽表达的意义.docVIP

精品论文 参考文献 探讨小儿先天性心脏病合并心力衰竭患者外周血中C—反应蛋白及脑钠肽表达的意义 黑龙江省嫩江县伊拉哈镇中心卫生院 161437 【摘 要】目的 研究分析C-反应蛋白（CRP）、脑钠肽（BNP）水平在小儿先天性心脏病（CHD）合并心力衰竭（CHF）患者外周血中的表达意义。方法 此次研究的对象是选取2010年1月～2015年12月本院的57例CHD患儿，将其临床资料进行回顾性分析，其中单纯CHD共14例，合并CHF共30例，合并CHF及肺炎共13例。同时随机抽取同期的小儿肺炎、健康小儿各20例。使用酶联免疫吸附法（ELISA）检测各组小儿外周血的CRP及BNP浓度，分析CHD合并CHF患者BNP及CRP水平与左心室射血分数（LVEF）的关系。结果 CHD合并CHF及肺炎组、CHD合并CHF组的CRP及BNP水平均显著高于肺炎组和健康组，差异有统计学意义（Plt;0.05）。单纯CHD组的BNP及CRP水平显著低于合并CHF及肺炎组与合并CHF组，差异有统计学意义（Plt;0.05）。CHD合并CHF组的CRP及BNP水平显著高于健康组和肺炎组，差异有统计学意义（Plt;0.05）。轻度组的CRP、BNP水平显著低于中度组和重度组，中度组的CRP及BNP水平显著低于重度组，差异有统计学意义（Plt;0.05）。BNP水平与CHD合并CHF组的LVEF呈负相关（Plt;0.05）。结论 CRP及BNP在小儿CHD合并CHF早期诊断中有一定协助作用，BNP可用于CHD合并CHF患儿心功能的评估。 　　【关键词】小儿先天性心脏病；心力衰竭；C-反应蛋白；脑钠肽 [Abstract] Objective To study the significance of expression of C- reactive protein （CRP） and brain natriuretic peptide （BNP） in peripheral blood of children with congenital heart disease （CHD） complicated with heart failure （CHF）. The object of this research method is from January 2010 to December 2015 in our hospital 57 cases of CHD patients，the retrospective analysis of the clinical data，including simple CHD a total of 14 cases，with a total of 30 cases of CHF combined with CHF and a total of 13 cases of pneumonia. At the same time，20 cases of children with pneumonia and healthy children were randomly selected from the same period. The concentrations of CRP and BNP in peripheral blood were detected by enzyme linked immunosorbent assay （ELISA），and the relationship between BNP and CRP levels and left ventricular ejection fraction （LVEF） in patients with CHD and CHF were analyzed. Results the levels of CRP and CHD in BNP combined with CHF and pneumonia group，CHD and CHF group were significantly higher than those in pneumonia group and healthy group，the difference was statistically significant （Plt;0.05）. The levels of BNP and CRP in CHD group were significantly lower than those in CHF group and pneumonia group and CHF group，the difference was statistically significant （Plt;0.05）. Th