单位肾脏体积GFR评价T1期肾肿瘤对GFR的影响.docVIP

单位肾脏体积GFR评价T1期肾肿瘤对GFR的影响 付德来 万紫妍 张亚萍 陈宏伟 李钊伦 王子明 种铁 李和程 西安交通大学医学院第二附属医院泌尿外科 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 目的 利用单位肾脏体积肾小球滤过率 (glomerular filtration rate per unit volume, GFR-UV) 评价T1期肾肿瘤对GFR的贡献。方法 回顾性分析2015年1月-2017年5月因肾肿瘤就诊于西安交通大学第二附属医院且资料完整的T1期肾肿瘤病例, 基于医学影像存档与通讯系统 (picture archiving and communication systems, PACS) 行肾脏体积、肿瘤体积测量, 采用ECT肾动态显像评估分肾功能, 计算单位肾脏体积GFR, 并根据单位肾脏体积GFR计算肿瘤对GFR的贡献。结果 健侧肾脏平均体积为 (161.78±34.73) mL, 患肾非肿瘤肾组织体积为 (157.83±36.60) mL, 肿瘤平均体积为 (35.41±27.79) mL。健侧GFR-UV为 (0.28±0.09) mL/min, 肿瘤对GFR的平均贡献为 (0.73±7.41) mL/min。结论 T1期肾肿瘤对患肾GFR贡献小, 保留肾单位手术后GFR下降主要由手术因素导致。 关键词： 肾癌; 保留肾单位手术; 肾小球率过滤; 作者简介：付德来 (1981-) , 男, 博士, 主治医师, 研究方向:微创泌尿外科技术;泌尿系肿瘤的基础与临床。 作者简介：李和程, 男, 主任医师, 研究方向:微创泌尿外科技术, 男科学, E-mail:lhch29@126.com。 收稿日期：2017-07-10 基金：国家自然科学基金 (810721-6) Application of GFR per unit volume in evaluating contribution of T1 Renal tumor on GFR FU Delai WAN Ziyan ZHANG Yaping CHEN Hongwei LI Zhaolun WANG Ziming CHONG Tie LI Hecheng Department of Urology, The Second Affiliated Hospital, Xian Jiaotong University; Abstract： Objective To explore the value of GFR per unit volume in evaluating contribution of stage T1 of renal tumor on GFR.Methods Patients with stage T1 of renal tumor were collected from Jan 2015 to May 2017.Volume of kidneys and tumors were measured based on the PACS (picture archiving and communication systems) .GFR of bilateral renal function was tested by radioactive isotopic scanning.Then GFR per unit volume of kidney was calculated, using which contribution of renal tumor on GFR to further evaluated.Results A total of 54 patients were enrolled in the study (32 males and 22 females) , in which 35 stage T1a and 19 stage T1b.Averaged volume of normal lateral kidney, affected lateral kidney (without tumor) and tumor were (161.78±34.73) mL, (157.83±36.60) mL and (35.41±27.79) mL, respectively.The GFR-UV of normal kidney was (0.28±0.09) mL/min.The average contribution to GFR of tumor was (0.73±7.4