曲马多用于术后镇痛的效果及安全性分析.docVIP

精品论文 参考文献 曲马多用于术后镇痛的效果及安全性分析 孙小英 奚柏剑 周小萍 徐美云 　　（江苏省扬中市中医院麻醉科 212200） 　　【摘要】目的：探讨曲马多用于术后镇痛的效果及安全性。方法：我院自2012年2月至2013年2月收治腹部手术患者84例，随机分为A、B、C三组，每组各28例，A组患者术后不给予曲马多镇痛，B组患者术后采用硬膜外腔给予曲马多镇痛，C组患者术后静脉给予曲马多镇痛。观察三组患者呼吸系统和循环系统情况，统计三组患者疼痛评分及副作用，评价曲马多镇痛的安全性。结果：呼吸系统和循环系统情况：平均动脉压、心率、呼吸频率无明显变化；在疼痛评分中，A组患者疼痛缓解时间最慢，且疼痛程度也最重，与B组和C组患者相比较，差异性具有统计学意义(P＜0.05)，疼痛程度和疼痛缓解时间在B组和C组患者之间相比较，差异性不具有统计学意义(P＞0.05)；主要出现了头晕、呕吐及恶心等副作用，最严重的是A组患者，但是与B组和C组患者相比较，差异性不具有统计学意义(P＞0.05)。结论：曲马多用于术后镇痛效果显著，能够明显减轻疼痛的程度及减少疼痛缓解的时间，术后应用曲马多不会影响呼吸系统和循环系统，采用静脉和硬膜外腔给予曲马多镇痛具有基本相同的镇痛效果，且术后给予曲马多可使得呕吐恶心等副作用得到减轻。 　　【关键词】曲马多 术后 镇痛 效果 安全性 疼痛缓解时间 疼痛程度 　　【中图分类号】R614 【文献标识码】A 【文章编号】2095-1752（2014）21-0387-02 　　【Abstract】Objective:To investigate the effect of tramadol analgesia effect and safety of postoperative.Method:84 cases in our hospital from 2012 February to 2013 February were abdominal operation patients,randomly divided into A,B,C three groups,28 cases in each group,not given tramadol A group patients,B groups of patients with postoperative epidural analgesia with tramadol,group C patients after intravenous.Tramadol analgesia.Observe three groups of patients with respiratory system and circulatory system,three patients pain score and side effects,safety evaluation of tramadol analgesia.Results:the respiratory system and the circulatory system:the mean arterial pressure,heart rate,respiratory rate had no significant change;in pain score in group A,patients with pain relief time most slowly,and the degree of pain is the most important,compared with B group and C group of patients, with statistically significant difference (Plt;0.05),pain and the degree of pain relief time comparison between B group and C group, the difference was not statistically significant (Pgt;0.05); mainly appeared dizziness,vomiting and nausea and other side effects,the most serious is the patients in the A group,but compared with B group and C group,the difference was not statistically signif