氟哌啶醇与利培酮治疗精神分裂症的疗效与影响因素分析.docVIP

精品论文 参考文献 氟哌啶醇与利培酮治疗精神分裂症的疗效与影响因素分析 孙林 胡召建 何小平 蒋德政 　　（重庆市垫江县精神卫生康复医院 重庆 新民 408303） 　　【摘要】 目的：评价氟哌啶醇与利培酮治疗偏执型精神分裂症的疗效并探讨其影响因素。方法：将2014年9月～2015年3月来我院就诊的92例偏执型精神分裂症患者随机分为氟哌啶醇组和利培酮组，按照PANSS减分率评价疗效，然后用单因素和多因素分析，探讨影响偏执型精神分裂症患者药物治疗疗效的影响因素。结果：氟哌啶醇与利培酮在治疗偏执型精神分裂症方面疗效相似（P＞0.05），影响药物治疗效果的影响因素有吸烟史、躯体状况、住院次数、病程、视觉简单反应时、视觉复杂反应时和听觉反应时。结论：吸烟史、躯体状况、住院次数、病程、视觉简单反应时、视觉复杂反应时和听觉反应时是影响氟哌啶醇与利培酮治疗偏执型精神分裂症效果的独立影响因素。 　　【关键词】 精神分裂症；氟哌啶醇；利培酮；疗效；影响因素 　　【中图分类号】R749.05 【文献标识码】A 【文章编号】2095-1752（2016）19-0048-03 　　Therapeutic effects and influencing factors of haloperidol and risperidone on paranoid schizophrenia 　　Sun Lin, Hu Zhaojian, He Xiaoping, Jiang Dezheng (Mental rehabilitation hospital of Dianjiang County, XinMin, 408303, Chongqing) 　　【Abstract】 Objective The purpose of this study was to evaluate the therapeutic effects and influencing factors of haloperidol and risperidone on paranoid schizophrenia. Methods 92 cases of paranoid schizophrenia who came to our hospital to see a doctor during September, 2014 to March, 2015 were randomly divided into haloperidol group and risperidone group. Therapeutic effects were evaluated by the Positive and Negative Syndrome Scale (PANSS) after patients were treated by haloperidol or risperidone for 8 weeks; After then, both single factor analysis and multifactor analysis were used to explore the possible influencing factors of antischizophrenic drugs on paranoid schizophrenia.Results Haloperidol or risperidone had similar therapeutic effects on paranoid schizophrenia (P＞0.05) ; Smoking history, Body condition, Numbers of hospitalization, Course of disease, Visual simple reaction time, Visual complex reaction time and Auditory reaction time were independently influencing factors of antischizophrenic drugs on paranoid schizophrenia. Conclusions Smoking history, Body condition, Numbers of hospitalization, Course of disease, Visual simple reaction time, Visual complex reaction time and Auditory reaction time were