中药、天然药物的研究与开发.pptVIP

Evolution of Drug Discovery HISTORICAL: Herbal extracts, trial and error 1800’s-1900’s: Pure substances (synthetic analogs) Aspirin - derived from salicilin isolated from willow tree (salix alba) Morphine – derived from poppy Ephedrine – derived from Ephedra sinica Mid - late 1900’s: Advance s and cell biology lead to better understanding of mechanism of action and the biochemical pathway of older drugs. Optimization lead to more specific drugs with fewer side effects Angiotensin II receptor antagonists for high blood pressure Evolution of Drug Discovery 1990’s - present: The Molecular Bio