烟酸缓释片治疗混合性高脂血症的疗效分析.docVIP

精品论文 参考文献 烟酸缓释片治疗混合性高脂血症的疗效分析 王小玲1 易国庆2（1广东广州开发区医院 510730;2广东萝岗区疾病预防控制中心 510730） 【中图分类号】R589.2【文献标识码】A【文章编号】1672-5085（2012）7-0113-02 【摘要】目的 通过临床研究证实烟酸缓释片在混合性高脂血症的治疗中具有确切的临床疗效。方法 对我院2010年3月—2011年3月治疗的85例高脂血症患者的临床资料进行回顾性分析，将患者随机分为两组，一组42例使用阿伐他汀进行治疗为对照组；一组43例使用烟酸缓释片进行治疗，观察组。研究对象治疗相同的疗程，对患者治疗前后的TC. TG. LDI-C，HDI-C、a-脂蛋白等血脂参数的变化率、患者的达标率、不良反应等临床数据进行比较。结果 治疗一定周期后，对患者进行疗效比较，在TG，a-脂蛋白降低和HDI-C升高方面的比较中，观察组有明显的优势，在不良反应及安全性方面，观察组患者的不良反应出现率较高，与对照组比较，无显著的统计学意义。结论 在混合性高脂血症的治疗中烟酸缓释片 能够有效地改善患者的血脂异常，在降低TG、升高HDGC和二脂蛋白方面尤为显著。耐受性、依从性不如阿伐他汀。 【关键词】阿伐他汀 烟酸缓释片 高脂血症 【Abstract】 objective through the clinical study confirms 53:25 nicotinic acid in the treatment of mixed hyperlipidemia is the exact clinical curative effect. Methods clinical data of 2010-2011 in March in March of 85 cases of hyperlipidemia treatment of patients with clinical data were retrospectively analyzed，will patients were randomly divided into two groups，one group 42 cases using atorvastatin treatment as control group; A group of 43 cases using nicotinic acid 53:25 treatment，the observation group. The research object treatment of the same treatment，the patients before and after treatment of TC. TG. LDI-C，HDI-C，A-lipoprotein (the rate of change of patients，blood fat parameters of the success rate，adverse reactions and clinical data are compared. Results the treatment period，compared to patients with curative effect，in TG，a-lipoprotein reduce and HDI-C rise of the comparison，the observation group has obvious advantages，and the adverse reactions and safety，the observation group of aderse eents in patients with higher rates，compared with controls，no significant statistical significance. Conclusion in the treatment of mixed hyperlipidemia 53:25 nicotinic acid can effectively improve patients with abnormal blood fat，reduce TG，rise in HDGC and two lipoprotein is especially significant aspects. Tolerance，compliance as atorvastatin. 【Key words】atorvastatin nicotinic acid 53:25 hyperlipidemia 近年来研究及临床实践证实，他汀类药物对血清低